4-(3-Aminophenyl)pyrrolidin-2-one

Base Information

Chemical Name:4-(3-Aminophenyl)pyrrolidin-2-one
CAS No.:725233-29-4
Molecular Formula:C10H12N2O
Molecular Weight:176.218
Hs Code.:
DSSTox Substance ID:DTXSID40458662

Synonyms:4-(3-aminophenyl)pyrrolidin-2-one;725233-29-4;SCHEMBL16977975;DTXSID40458662;MFCD15144683;AKOS022183425;AS-38300;CS-0455266;FT-0770008;EN300-113095;Z1255401112

Suppliers and Price of 4-(3-Aminophenyl)pyrrolidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 4-(3-Aminophenyl)pyrrolidin-2-one

Chemical Property:

XLogP3:0.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:176.094963011
Heavy Atom Count:13
Complexity:205

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(CNC1=O)C2=CC(=CC=C2)N

Technology Process of 4-(3-Aminophenyl)pyrrolidin-2-one

There total 1 articles about 4-(3-Aminophenyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1664-59-1
3-(3-nitrophenyl)acrylic acid methyl ester

: 725233-29-4
4-(3-aminophenyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 48 percent / 1,1,3,3-tetramethylguanidine / 0.5 h / 80 °C

2: 57 percent / RaNi 2800; H₂ / methanol / 16 h / 60 °C / 3040 Torr

With RaNi 2800; hydrogen; N,N,N',N'-tetramethylguanidine; In methanol;
DOI:10.1021/jm030551a

Reference yield: 87.0%

: 594-44-5
Ethanesulfonyl chloride

: 725233-29-4
4-(3-aminophenyl)pyrrolidin-2-one

: 725233-30-7
ethanesulfonic acid [3-(5-oxopyrrolidin-3-yl)phenyl]amide

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃;
DOI:10.1021/jm030551a

Reference yield:

: 725233-29-4
4-(3-aminophenyl)pyrrolidin-2-one

: ethanesulfonic acid (3-pyrrolidin-3-yl-phenyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 87 percent / pyridine / CH₂Cl₂ / 20 °C

2.1: BH₃*THF / tetrahydrofuran / Heating

2.2: 59 percent / aq. HCl / tetrahydrofuran / 1 h / Heating

With pyridine; borane-THF; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm030551a