N-[3-(5-oxopyrrolidin-3-yl)phenyl]ethanesulfonamide

Base Information

Chemical Name:N-[3-(5-oxopyrrolidin-3-yl)phenyl]ethanesulfonamide
CAS No.:725233-30-7
Molecular Formula:C₁₂H₁₆N₂O₃S
Molecular Weight:268.337
Hs Code.:
DSSTox Substance ID:DTXSID801225518

Synonyms:725233-30-7;DTXSID801225518;N-[3-(5-Oxo-3-pyrrolidinyl)phenyl]ethanesulfonamide

Suppliers and Price of N-[3-(5-oxopyrrolidin-3-yl)phenyl]ethanesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[3-(5-oxopyrrolidin-3-yl)phenyl]ethanesulfonamide

Chemical Property:

XLogP3:0.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:268.08816355
Heavy Atom Count:18
Complexity:402

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCS(=O)(=O)NC1=CC=CC(=C1)C2CC(=O)NC2

Technology Process of N-[3-(5-oxopyrrolidin-3-yl)phenyl]ethanesulfonamide

There total 3 articles about N-[3-(5-oxopyrrolidin-3-yl)phenyl]ethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 594-44-5
Ethanesulfonyl chloride

: 725233-29-4
4-(3-aminophenyl)pyrrolidin-2-one

: 725233-30-7
ethanesulfonic acid [3-(5-oxopyrrolidin-3-yl)phenyl]amide

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃;
DOI:10.1021/jm030551a

Reference yield:

: 1664-59-1
3-(3-nitrophenyl)acrylic acid methyl ester

: 725233-30-7
ethanesulfonic acid [3-(5-oxopyrrolidin-3-yl)phenyl]amide

Guidance literature:: Multi-step reaction with 3 steps

1: 48 percent / 1,1,3,3-tetramethylguanidine / 0.5 h / 80 °C

2: 57 percent / RaNi 2800; H₂ / methanol / 16 h / 60 °C / 3040 Torr

3: 87 percent / pyridine / CH₂Cl₂ / 20 °C

With pyridine; RaNi 2800; hydrogen; N,N,N',N'-tetramethylguanidine; In methanol; dichloromethane;
DOI:10.1021/jm030551a

Reference yield:

: 372944-93-9
4-nitro-3-(3-nitrophenyl)butyric acid methyl ester

: 725233-30-7
ethanesulfonic acid [3-(5-oxopyrrolidin-3-yl)phenyl]amide

Guidance literature:: Multi-step reaction with 2 steps

1: 57 percent / RaNi 2800; H₂ / methanol / 16 h / 60 °C / 3040 Torr

2: 87 percent / pyridine / CH₂Cl₂ / 20 °C

With pyridine; RaNi 2800; hydrogen; In methanol; dichloromethane;
DOI:10.1021/jm030551a