2,2'-Methylenedipiperidine

Base Information

• Chemical Name: 2,2'-Methylenedipiperidine
• CAS No.: 25382-41-6
• Molecular Formula: C₁₁H₂₂N₂
• Molecular Weight: 182.309
• Mol file: 25382-41-6.mol

Synonyms:2,2'-Methylenedipiperidine

Chemical Property of 2,2'-Methylenedipiperidine

Chemical Property:

• Melting Point: 54 - 55 °C
• PSA: 24.06000
• LogP: 2.31830

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2'-Methylenedipiperidine

There total 9 articles about 2,2'-Methylenedipiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

bis(6-oxopiperidin-2-yl)methane → bis(2-piperidinyl)methane (25382-41-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 4h; Inert atmosphere; Reflux;

DOI:10.1002/ejoc.201801075

Reference yield: 66.0%

bis(2-pyridyl)methane (1132-37-2) → bis(2-piperidinyl)methane (25382-41-6)

Guidance literature:

With rhodium contaminated with carbon; hydrogen; acetic acid; In methanol; for 72h; under 63756.4 Torr; Autoclave;

DOI:10.1002/ejoc.201801075

Reference yield:

2,2'-methylenedicyclopentanone (55100-61-3) → bis(2-piperidinyl)methane (25382-41-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; sodium azide / chloroform / -15 °C / Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 °C / Inert atmosphere; Reflux

With lithium aluminium tetrahydride; sodium azide; sulfuric acid; In tetrahydrofuran; chloroform; 1: |Schmidt Reaction;

DOI:10.1002/ejoc.201801075

upstream raw materials:

2,2'-methylenedicyclopentanone

bis(2-pyridyl)methane

cyclopentanone

pyridine

Refernces