Technology Process of Spermexatin
There total 8 articles about Spermexatin which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
ethanol;
for 4h;
Ambient temperature;
DOI:10.1021/jm00122a013
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 97 percent / 1,3-dicyclohexylcarbodiimide / tetrahydrofuran / 1.) 0-5 deg C, 3 h, 2.) room temperature, 15 h
2: 52 percent / DMAP / tetrahydrofuran / 16 h / Ambient temperature
3: 83 percent / H2 / 10percent Pd/C / ethanol / 4 h / Ambient temperature
With
dmap; hydrogen; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol;
DOI:10.1021/jm00122a013
- Guidance literature:
-
Multi-step reaction with 4 steps
1: DMAP / CH2Cl2 / 16 h
2: 1.) HBr/HOAc (33percent), 2.) NaHCO3 / 1.) 4 h, room temperature, 2.) H2O, ethyl acetate, 24 h, room temperature
3: 1.) N,N'-carbonyldiimidazole / 1.) CH2Cl2, 1 h, room temperature, 2.) CH2Cl2, 8 h
4: 83 percent / H2 / 10percent Pd/C / ethanol / 4 h / Ambient temperature
With
dmap; hydrogen bromide; hydrogen; sodium hydrogencarbonate; acetic acid; 1,1'-carbonyldiimidazole;
palladium on activated charcoal;
In
ethanol; dichloromethane;
DOI:10.1021/jm00122a013
