89965-56-0Relevant articles and documents
Stereoselective synthesis of novel ptilomycalin a analogs via successive 1,3-dipolar cycloaddition reactions and their Ca2+-ATPase inhibitory activity
Georgieva, Angelina,Hirai, Manabu,Hashimoto, Yuichi,Nakata, Tadashi,Ohizumi, Yasushi,Nagasawa, Kazuo
, p. 1427 - 1432 (2007/10/03)
The pentacyclic guanidine compounds 4 and 5 were stereoselectively synthesized as novel ptilomycalin A and crambescidin analogs. The synthetic method involves successive 1,3-dipolar cycloaddition reactions which effectively access the key intermediates, t
49. Synthesis of tenuilobine, a bis-polyamine alkaloid from Oncinotis tenuiloba, and its transamidation to isotenuilobine
Doll, Martin K.-H.,Guggisberg, Armin,Hesse, Manfred
, p. 541 - 547 (2007/10/03)
From the leaves of Oncinotis tenuiloba STAPF, a novel polyamine alkaloid, tenuilobine (9), was isolated. This paper presents the synthesis of 9, as well as the base-catalyzed Zip reaction of 9, leading to the transamidation product isotenuilobine (10). Th
Spermexatin and Spermexatol: New Synthetic Spermidine-Based Siderophore Analogues
Sharma, Sushil K.,Miller, Marvin J.,Payne, Shelley M.
, p. 357 - 367 (2007/10/02)
Syntheses of hexanediamine-based dihydroxamate (Hexamate), spermidine-based trihydroxamate (Spermexatins), and spermidine-based mixed siderophore analogues (Spermexatols) are described.Key intermediates include the N-hydroxysuccinimide esters of various hydroxamic acids, e.g., malonohydroxamate, succinohydroxamate, and glutarohydroxamate.These intermediates were synthesized, characterized, and incorporated as the ligating chains on spermidine.Also, mixed iron chelating compounds (Spermexatols) with both catechol and hydroxamic acid side chains were synthesized.Thereagent carbobenzoxyimidazole was employed to distinguish between the primary and secondary amino groups of spermidine.The ability of these iron chelators to stimulate microbial growth is also described.
