4-Phenylpyridine-2-carboxaldehyde

Base Information

• Chemical Name: 4-Phenylpyridine-2-carboxaldehyde
• CAS No.: 55218-76-3
• Molecular Formula: C12H9NO
• Molecular Weight: 183.21
• Hs Code.: 2933399090
• European Community (EC) Number: 827-343-6
• DSSTox Substance ID: DTXSID00480944
• Wikidata: Q82316104
• Mol file: 55218-76-3.mol

Synonyms:55218-76-3;4-PHENYLPICOLINALDEHYDE;4-Phenylpyridine-2-carboxaldehyde;4-phenylpyridine-2-carbaldehyde;4-phenyl-pyridine-2-carbaldehyde;2-formyl-4-phenylpyridine;SCHEMBL2084619;DTXSID00480944;AAUMFILRCKHZQP-UHFFFAOYSA-N;MFCD14702184;SY278654;CS-0243213;FT-0762698;EN300-2608533;Z1255381072

Chemical Property of 4-Phenylpyridine-2-carboxaldehyde

Chemical Property:

• PSA: 29.96000
• LogP: 2.56110
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 183.068413911
• Heavy Atom Count: 14
• Complexity: 187

Purity/Quality:

97% ^*data from raw suppliers

4-Phenylpicolinaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC(=NC=C2)C=O

Technology Process of 4-Phenylpyridine-2-carboxaldehyde

There total 5 articles about 4-Phenylpyridine-2-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-(dimethoxymethyl)-4-phenylpyridine → 4-phenyl-2-pyridinaldehyde (55218-76-3)

Guidance literature:

With sulfuric acid; In water; at 80 ℃; for 2h;

Reference yield: 78.0%

2-(hydroxymethyl)-4-phenylpyridine (55218-73-0) → 4-phenyl-2-pyridinaldehyde (55218-76-3)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; Reflux;

Reference yield:

N-Formylpiperidine (2591-86-8) + 2-bromo-4-phenylpyridine (54151-74-5) → 4-phenyl-2-pyridinaldehyde (55218-76-3)

Guidance literature:

2-bromo-4-phenylpyridine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

N-Formylpiperidine; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 2h;

With hydrogenchloride; water; In tetrahydrofuran; hexane;

upstream raw materials:

N-Formylpiperidine

2-bromo-4-phenylpyridine

2-(hydroxymethyl)-4-phenylpyridine

phenylboronic acid

Downstream raw materials:

2,2,2-trifluoro-1-(4-phenylpyridin-2-yl)ethanol

C₁₉H₁₈N₂