(5-AMino-1H-pyrazol-3-yl)Methanol

Base Information

• Chemical Name: (5-AMino-1H-pyrazol-3-yl)Methanol
• CAS No.: 1000895-26-0
• Molecular Formula: C₄H₇N₃O
• Molecular Weight: 113.119
• Mol file: 1000895-26-0.mol

Synonyms:(5-AMino-1H-pyrazol-3-yl)Methanol;5-amino-1H-Pyrazole-3-methanol

Chemical Property of (5-AMino-1H-pyrazol-3-yl)Methanol

Chemical Property:

• Boiling Point: 456.1±30.0 °C(Predicted)
• PKA: 13.52±0.10(Predicted)
• PSA: 74.93000
• Density: 1.467±0.06 g/cm3(Predicted)
• LogP: 0.06540
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%min ^*data from raw suppliers

(3-Amino-1H-pyrazol-5-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (5-AMino-1H-pyrazol-3-yl)Methanol

There total 2 articles about (5-AMino-1H-pyrazol-3-yl)Methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

5-nitropyrazole-3-carboxylic acid (198348-89-9) → (3-amino-1H-pyrazol-5-yl)methanol (1000895-26-0,948571-48-0)

Guidance literature:

With ammonium formate; palladium 10% on activated carbon; In ethanol; at 140 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

methyl 5-amino-1H-pyrazole-3-carboxylate (632365-54-9) → (3-amino-1H-pyrazol-5-yl)methanol (1000895-26-0,948571-48-0)

Guidance literature:

methyl 5-amino-1H-pyrazole-3-carboxylate; With lithium borohydride; In tetrahydrofuran; for 16h; Heating / reflux;

With methanol; In tetrahydrofuran;

Reference yield:

(3-amino-1H-pyrazol-5-yl)methanol (1000895-26-0,948571-48-0) + [5-tert-butyl-2-(4-methylphenyl)-2H-pyrazol-3-yl]carbamic acid phenyl ester (285984-47-6) → C19H24N6O2 (1415484-35-3)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; at 80 ℃; for 16h;

DOI:10.1016/j.bmcl.2012.10.039

upstream raw materials:

5-nitropyrazole-3-carboxylic acid

methyl 5-amino-1H-pyrazole-3-carboxylate

Downstream raw materials:

C₁₉H₂₄N₆O₂

Refernces

• 1、 -. "QUINOLINE DERIVATIVES". Page/Page column 116. . Retrieved 2008/06/13.