5-(difluoromethyl)picolinic acid

Base Information

• Chemical Name: 5-(difluoromethyl)picolinic acid
• CAS No.: 859538-41-3
• Molecular Formula: C₇H₅F₂NO₂
• Molecular Weight: 173.119
• Hs Code.: 2933399990
• Mol file: 859538-41-3.mol

Synonyms:5-(difluoromethyl)picolinic acid;5-(DIFLUOROMETHYL)PYRIDINE-2-CARBOXYLIC ACID

Chemical Property of 5-(difluoromethyl)picolinic acid

Chemical Property:

• PSA: 50.19000
• LogP: 1.71740

Purity/Quality:

97% ^*data from raw suppliers

5-(Difluoromethyl)pyridine-2-carboxylic acid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(difluoromethyl)picolinic acid

There total 6 articles about 5-(difluoromethyl)picolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-(difluoromethyl)pyridine-2-carbonitrile (1211540-57-6) → 5-(difluoromethyl)picolinic acid (859538-41-3)

Guidance literature:

With hydrogenchloride; water; at 110 ℃; for 1.5h;

Reference yield: 62.0%

5-difluoromethyl-pyridine-2-carboxylic acid methyl ester (1346148-42-2) → 5-(difluoromethyl)picolinic acid (859538-41-3)

Guidance literature:

5-difluoromethyl-pyridine-2-carboxylic acid methyl ester; With lithium hydroxide; In ethanol; at 0 - 20 ℃; for 5h;

With citric acid; In water; pH=~ 4;

Reference yield:

6-bromonicotinaldehyde (149806-06-4) → 5-(difluoromethyl)picolinic acid (859538-41-3)

Guidance literature:

Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide; ethyl acetate; n-heptane

2: n-heptane; toluene

3: hydrogenchloride / liquid HCl

In hydrogenchloride; n-heptane; ethyl acetate; N,N-dimethyl-formamide; toluene;

upstream raw materials:

2-bromo-5-(difluoromethyl)pyridine

5-difluoromethyl-pyridine-2-carboxylic acid methyl ester

6-bromonicotinaldehyde

2-cyanopyridine-5-carboxyaldehyde

Downstream raw materials:

N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)-5-(difluoromethyl)picolinamide

N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluoro-5-methylphenyl)-5-(difluoromethyl)picolinamide

N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-(difluoromethyl)picolinamide

Refernces

• 1、 -. "BRIDGED BICYCLIC AMINO THIAZINE DIOXIDE COMPOUNDS AS INHIBITORS OF BETA-SECRETASE AND METHODS OF USE THEREOF". . . Retrieved 2015/02/19.
• 2、 -. "AMINO-DIHYDROTHIAZINE AND AMINO-DIOXIDO DIHYDROTHIAZINE COMPOUNDS AS BETA-SECRETASE ANTAGONISTS AND METHODS OF USE". . . Retrieved 2014/05/07.