5-Formylpicolinonitrile

Base Information

Chemical Name:5-Formylpicolinonitrile
CAS No.:131747-68-7
Molecular Formula:C7H4 N2 O
Molecular Weight:132.122
Hs Code.:2933399090
European Community (EC) Number:871-375-3
DSSTox Substance ID:DTXSID80450726
Wikidata:Q82270531
Mol file:131747-68-7.mol

Synonyms:131747-68-7;5-FORMYLPICOLINONITRILE;5-formylpyridine-2-carbonitrile;5-FORMYL-2-PYRIDINECARBONITRILE;2-PYRIDINECARBONITRILE, 5-FORMYL-;MFCD12755972;SCHEMBL450834;6-cyano-3-pyridinecarboxaldehyde;6-Cyanopyridine-3-carboxaldehyde;DTXSID80450726;ZYOAZOZQOTWMEE-UHFFFAOYSA-N;AKOS015837488;AB66011;CS-W018580;GS-6656;PD160392;SY031878;FT-0737276;EN300-73114;Not available;5-Formyl-2-pyridinecarbonitrile;A856212;W-205377

Suppliers and Price of 5-Formylpicolinonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6-Cyanopyridine-3-carboxaldehyde
10g
$ 1135.00

SynQuest Laboratories
5-Formylpyridine-2-carbonitrile
5 g
$ 608.00

SynQuest Laboratories
5-Formylpyridine-2-carbonitrile
1 g
$ 152.00

Matrix Scientific
5-Formyl-2-pyridinecarbonitrile 95+%
500mg
$ 200.00

Matrix Scientific
5-Formyl-2-pyridinecarbonitrile 95+%
1g
$ 355.00

Matrix Scientific
5-Formyl-2-pyridinecarbonitrile 95+%
5g
$ 998.00

Crysdot
5-Formylpicolinonitrile 97+%
10g
$ 960.00

Crysdot
5-Formylpicolinonitrile 97+%
100g
$ 4144.00

Crysdot
5-Formylpicolinonitrile 97+%
5g
$ 493.00

Crysdot
5-Formylpicolinonitrile 97+%
25g
$ 1820.00

Total 39 raw suppliers

Chemical Property of 5-Formylpicolinonitrile

Chemical Property:

Boiling Point:331.3±27.0 °C(Predicted)
PKA:-2.12±0.10(Predicted)
PSA：53.75000
Density:1.24±0.1 g/cm3(Predicted)
LogP:0.76578
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
Solubility.:Chloroform, Methanol
XLogP3:0.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:132.032362755
Heavy Atom Count:10
Complexity:170

Purity/Quality:

99%, ^*data from raw suppliers

6-Cyanopyridine-3-carboxaldehyde ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=NC=C1C=O)C#N
Uses 6-Cyanopyridine-3-carboxaldehyde, is an intermediate used for the synthesis of pharmaceutical compounds, such as GLPG0634 (C982190), which is used for treatment of rheumatoid arthritis

Technology Process of 5-Formylpicolinonitrile

There total 8 articles about 5-Formylpicolinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 671776-91-3
5-(1,3-dioxolan-2-yl)-2-cyano-pyridine

: 131747-68-7
2-cyanopyridine-5-carboxyaldehyde

Guidance literature:: With hydrogenchloride; water; In tetrahydrofuran; at 20 - 50 ℃; for 29h; Inert atmosphere;

Reference yield: 77.0%

: 58553-48-3
5-(hydroxymethyl)pyridine-2-carbonitrile

: 131747-68-7
2-cyanopyridine-5-carboxyaldehyde

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 0.333333h;

5-(hydroxymethyl)pyridine-2-carbonitrile; In dichloromethane; at -78 ℃; for 2h;

With triethylamine; In dichloromethane; at 20 ℃;

Reference yield: 77.0%

: 79-37-8
oxalyl dichloride

: 58553-48-3
5-(hydroxymethyl)pyridine-2-carbonitrile

: 131747-68-7
2-cyanopyridine-5-carboxyaldehyde

Guidance literature:: oxalyl dichloride; With dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 0.333333h;

5-(hydroxymethyl)pyridine-2-carbonitrile; In dichloromethane; at -78 ℃; for 2h;

With triethylamine; In dichloromethane;