6-Methyl-5-(4-nitrophenyl)thieno[2,3-d]pyrimidin-4-amine

Base Information

Chemical Name:6-Methyl-5-(4-nitrophenyl)thieno[2,3-d]pyrimidin-4-amine
CAS No.:605661-12-9
Molecular Formula:C13H10N4O2S
Molecular Weight:286.314
Hs Code.:
DSSTox Substance ID:DTXSID301199168

Synonyms:6-methyl-5-(4-nitrophenyl)thieno[2,3-d]pyrimidin-4-amine;605661-12-9;SCHEMBL4473203;XLPZHFDZDZITNH-UHFFFAOYSA-N;DTXSID301199168;A849675

Suppliers and Price of 6-Methyl-5-(4-nitrophenyl)thieno[2,3-d]pyrimidin-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 6-Methyl-5-(4-nitrophenyl)thieno[2,3-d]pyrimidin-4-amine

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:1
Exact Mass:286.05244675
Heavy Atom Count:20
Complexity:370

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C2=C(N=CN=C2S1)N)C3=CC=C(C=C3)[N+](=O)[O-]

Technology Process of 6-Methyl-5-(4-nitrophenyl)thieno[2,3-d]pyrimidin-4-amine

There total 4 articles about 6-Methyl-5-(4-nitrophenyl)thieno[2,3-d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 605661-11-8
2-amino-5-methyl-4-(4-nitrophenyl)thiophene-3-carbonitrile

: 77287-34-4,77287-35-5,60100-09-6
formamide

: 605661-12-9
6-methyl-5-(4-nitrophenyl)thieno[2,3-d]pyrimidin-4-amine

Guidance literature:: at 155 ℃; for 17h;
DOI:10.1021/jm050458h

Reference yield:

: 605661-10-7
2-[1-(4-nitrophenyl)propylidene]malononitrile

: 605661-12-9
6-methyl-5-(4-nitrophenyl)thieno[2,3-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / Et₂NH; sulfur / ethanol / 1.5 h / 70 °C

2: 93 percent / 17 h / 155 °C

With sulfur; diethylamine; In ethanol; 1: Gewald reaction;
DOI:10.1021/jm050458h

Reference yield:

: 3758-70-1
1-(4-nitrophenyl)propan-1-one

: 605661-12-9
6-methyl-5-(4-nitrophenyl)thieno[2,3-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / NH₄OAc; AcOH / benzene / 18 h / Heating

2: 85 percent / Et₂NH; sulfur / ethanol / 1.5 h / 70 °C

3: 93 percent / 17 h / 155 °C

With ammonium acetate; sulfur; acetic acid; diethylamine; In ethanol; benzene; 1: Knoevenagel condensation / 2: Gewald reaction;
DOI:10.1021/jm050458h