3758-70-1

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-Nitrophenyl)propan-1-one is used as a key intermediate in the synthesis of various pharmaceuticals for [application reason]. Its unique chemical structure allows it to be a versatile building block in the development of new drugs and medications.
Used in Organic Synthesis:
In the field of organic synthesis, 1-(4-Nitrophenyl)propan-1-one is used as a reagent or starting material for the preparation of a wide range of organic compounds. Its ability to undergo various chemical reactions makes it a valuable component in the synthesis of complex organic molecules.
Used in Research and Development:
1-(4-Nitrophenyl)propan-1-one is also utilized in research and development settings as a model compound for studying various chemical reactions and processes. Its properties and reactivity can provide valuable insights into the behavior of similar compounds and contribute to the advancement of chemical knowledge.

InChI:InChI=1/C9H9NO3/c1-2-9(11)7-3-5-8(6-4-7)10(12)13/h3-6H,2H2,1H3

Upstream product

• 62558-06-9 1-(4-nitrophenyl)-1-propanol 
• 34812-95-8 1,3-di-tert-butyl 2-methylpropanedioate 
• 122-04-3 4-nitro-benzoyl chloride 
• 62558-00-3 p-(1-Chlorpropyl)-nitrobenzol 
• 69709-35-9 1-(1-Benzenesulfonyl-propyl)-4-nitro-benzene 
• 79-24-3 Nitroethane 
• 555-16-8 4-nitrobenzaldehdye 
• 93-55-0 1-phenyl-propan-1-one 
• 3769-81-1 4-Nitro-propiophenon-anil 
• 586-78-7 para-nitrophenyl bromide 
• 2386-64-3 ethylmagnesium chloride 
• 3249-50-1 1-propenyl acetate 
• 1067-52-3 tributyltin methoxide 
• 93-54-9 1-Phenyl-1-propanol 

Downstream Products

• 70-69-9 1-(4-aminophenyl)-1-propanone 
• 60644-67-9 2-methyl-3-(p-nitrophenyl)-1-propene-3-one 
• 1205-56-7 2-bromo-1-(4-nitrophenyl)propan-1-one 
• 1235997-90-6 (2E)-2-methyl-3-(2-naphthyl)-1-(4-nitrophenyl)prop-2-en-1-one 
• 4210-10-0 3-(4-chlorophenylamino)-3-phenyl-1-(4-nitrophenylpropan)-1-one 
• 1279103-44-4 2-(2,6-Difluoro-phenyl)-5-(5-methyl-2-pyridin-2-yl-thiazol-4-yl)-1H-indole 
• 1279106-29-4 2-[5-Methyl-4-(4-nitro-phenyl)-thiazol-2-yl]-pyridine 
• 1017118-68-1 4-(5-Methyl-2-pyridin-2-yl-thiazol-4-yl)-phenylamine 
• 1279106-31-8 (E)-N-[1-(2,6-difluorophenyl)ethylidene]-N'-[1-(5-methyl-2-pyridin-2-ylthiazol-4-yl)phenyl]hydrazine 
• 1345507-91-6 C₁₂H₁₁N₃O₂ 
• 16942-62-4 2-amino-4-(4’-nitrophenyl)-5-methyl-1,3-thiazole 

Relevant academic research and scientific papers

Visible-Light-Driven Direct Oxidative Coupling Reaction Leading to Alkyl Aryl Ketones, Catalyzed by Nano Pd/ZnO

Direct alkyl sp3 C–H activation to form new C–C bonds is one of the major challenges in synthetic chemistry. Herein, for the first time, we represent a new method, using nano Pd/ZnO which plays both as photoredox and transition-metal catalyst, for C–C bond formations. By using this catalyst, we have accomplished an oxidative coupling reaction between aryl halides and tertiary amines to yield the corresponding naturally occurring alkyl aryl ketones by using visible light irradiation. Furthermore, the carbonylation process was carried out on a 10 gram scale, with visible light and thermal condition, and it was proved to be scalable, efficient, and economical.

Chemoselective synthesis of ketones and ketimines by addition of organometallic reagents to secondary amides

The development of efficient and selective transformations is crucial in synthetic chemistry as it opens new possibilities in the total synthesis of complex molecules. Applying such reactions to the synthesis of ketones is of great importance, as this motif serves as a synthetic handle for the elaboration of numerous organic functionalities. In this context, we report a general and chemoselective method based on an activation/addition sequence on secondary amides allowing the controlled isolation of structurally diverse ketones and ketimines. The generation of a highly electrophilic imidoyl triflate intermediate was found to be pivotal in the observed exceptional functional group tolerance, allowing the facile addition of readily available Grignard and diorganozinc reagents to amides, and avoiding commonly observed over-addition or reduction side reactions. The methodology has been applied to the formal synthesis of analogues of the antineoplastic agent Bexarotene and to the rapid and efficient synthesis of unsymmetrical diketones in a one-pot procedure. Macmillan Publishers Limited. All rights reserved.

Pentamethylcyclopentadienyl ruthenium: an efficient catalyst for the redox isomerization of functionalized allylic alcohols into carbonyl compounds

The catalytic activity of the ruthenium(II) complex [RuCp*(CH3CN)3][PF6] 1 in the transposition of allylic alcohols into carbonyl compounds, in acetonitrile, is reported. This catalyst has proven to be able to catalyze the transformation of poorly reactive and/or functionalized substrates under smooth conditions.

Development of a robust and practical process for the Darzens condensation and α,β-epoxide rearrangement: Scope and limitations of the methodology

A practical and robust process for the Darzens condensation of substituted benzaldehydes and subsequent α,β-epoxy rearrangement is reported. The process developed is both amenable to large scale and parallel synthesis. While electron-poor benzaldehydes gave mixtures of aryl ketones and 2-substituted aryl ketones in mediocre to low yields, electron-rich benzaldehydes were found to react in high yields with complete regioselectivity to form 2-substituted aryl ketones. Georg Thieme Verlag Stuttgart.

Unexpected formation of aryl ketones by palladium-catalyzed coupling of aryl bromides with vinylic acetates

A palladium-catalyzed coupling reaction of aryl bromides with vinylic acetates in the presence of tributyitin methoxide has been described. Unexpected formation of aryl ketones was obtained. Preliminary mechanistic studies indicated that the reaction proceeded by the addition of the aryl moiety in the coordination sphere of palladium to a ketene.

Thienopyrimidine ureas as novel and potent multitargeted receptor tyrosine kinase inhibitors

A series of novel thienopyrimidine-based receptor tyrosine kinase inhibitors has been discovered. Investigation of structure-activity relationships at the 5- and 6-positions of the thienopyrimidine nucleus led to a series of N,N′-diaryl ureas that potentl

Thiopyrimidine and isothiazolopyrimidine kinase inhibitors

Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Kinase inhibitors

The present application is directed to pyrazolopyrirnidine and furopyrimidine analogs of the formula (I) wherein the substituents are as defined herein, which are useful as kinase inhibitors.

Thiopyrimidine and isothiazolopyrimidine kinase inhibitors

Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Thiopyrimidine and isothiazolopyrimidine kinase inhibitors

Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compound, compositions containing the compounds, and methods of treatment using the compounds.