1-BroMo-2-(trifluoroMethoxy)ethane

Base Information

• Chemical Name: 1-BroMo-2-(trifluoroMethoxy)ethane
• CAS No.: 1645-93-8
• Molecular Formula: C3H4BrF3O
• Molecular Weight: 192.963
• Hs Code.: 2909199090
• Mol file: 1645-93-8.mol

Synonyms:1-BroMo-2-(trifluoroMethoxy)ethane

Chemical Property of 1-BroMo-2-(trifluoroMethoxy)ethane

Chemical Property:

• Refractive Index: n20/D1.367
• Boiling Point: 77-80 °C
• Flash Point: 110℃
• PSA: 9.23000
• Density: 1.674 g/mL at 25 °C
• LogP: 1.91770
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Bromo-2-(trifluoromethoxy)ethane ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Bromo-2-(trifluoromethoxy)ethane (cas# 1645-93-8) is used as a reactant in the preparation of non-fused tricyclic compounds for treatment of cancer.

Technology Process of 1-BroMo-2-(trifluoroMethoxy)ethane

There total 2 articles about 1-BroMo-2-(trifluoroMethoxy)ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.0%

oxalyl difluoride (359-40-0) + 2-bromoethyl methanesulfonate (4239-10-5) → 2,2,3,3-tetrafluoro-1,4-dioxan (56625-47-9) + 1-bromo-2-(trifluoromethoxy)ethane (1645-93-8)

Guidance literature:

With potassium fluoride; dibenzo-18-crown-6; In diethylene glycol dimethyl ether; at 140 ℃; for 60h; Title compound not separated from byproducts;

DOI:10.1016/S0022-1139(00)81237-3

Reference yield:

Carbonyl fluoride (353-50-4) + 2-bromoethanol (540-51-2) → 1-bromo-2-(trifluoromethoxy)ethane (1645-93-8)

Guidance literature:

Multistep reaction; (i), (ii) SF₄;

DOI:10.1021/jo01024a002

Reference yield: 50.0%

1-bromo-2-(trifluoromethoxy)ethane (1645-93-8) + 1-(2-phenyl-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-3-(trans-4-phenylpyrrolidin-3-yl)urea hydrochloride → 1-(trans-4-phenyl-1-(2-(trifluoromethoxy)ethyl)pyrrolidin-3-yl)-3-(2-phenyl-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)urea

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 - 40 ℃; for 18h;

upstream raw materials:

Carbonyl fluoride

2-bromoethanol

oxalyl difluoride

2-bromoethyl methanesulfonate

Refernces