5-CHLORO-8-NITROQUINAZOLIN-4-OL

Base Information

• Chemical Name: 5-CHLORO-8-NITROQUINAZOLIN-4-OL
• CAS No.: 400784-50-1
• Molecular Formula: C8H4ClN3O3
• Molecular Weight: 225.591
• Mol file: 400784-50-1.mol

Synonyms:5-CHLORO-8-NITROQUINAZOLIN-4-OL;5-chloro-8-nitro-4(3H)-Quinazolinone

Chemical Property of 5-CHLORO-8-NITROQUINAZOLIN-4-OL

Chemical Property:

• PSA: 91.83000
• LogP: 2.42020

Purity/Quality:

97% ^*data from raw suppliers

5-CHLORO-8-NITROQUINAZOLIN-4-OL 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-CHLORO-8-NITROQUINAZOLIN-4-OL

There total 7 articles about 5-CHLORO-8-NITROQUINAZOLIN-4-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

5-chloroquinazoline-4(3H)-one (60233-66-1) → 5-chloro-8-nitro-quinazolin-4(3H)-one (400784-50-1)

Guidance literature:

With sulfuric acid; nitric acid; for 2h; Cooling with ice;

DOI:10.1134/S107036322109022X

Reference yield: 51.6%

5-chloroquinazolin-4-ol (60233-66-1) → 4-hydroxy-5-chloro-8-nitro-quinazoline (400784-50-1)

Guidance literature:

With sulfuric acid; nitric acid; at 0 ℃; for 0.166667h;

DOI:10.1016/j.bmc.2005.05.045

Reference yield:

N-(3-chloro-2-methylphenyl)acetamide (7463-35-6) → 4-hydroxy-5-chloro-8-nitro-quinazoline (400784-50-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 65.7 percent / potassium permanganate; magnesium sulfate heptahydrate / H₂O / 5 h / 135 - 160 °C

2: hydrochloric acid / 1.5 h / 80 - 90 °C

3: 67.6 percent / 2 h / 130 - 175 °C

4: 51.6 percent / H₂SO₄; nitric acid / 0.17 h / 0 °C

With hydrogenchloride; potassium permanganate; sulfuric acid; nitric acid; magnesium sulfate; In water;

DOI:10.1016/j.bmc.2005.05.045

upstream raw materials:

5-chloroquinazolin-4-ol

N-(3-chloro-2-methylphenyl)acetamide

2-chloro-6-aminobenzoic acid

3-chloro-2-methylbenzenamine

Refernces

• 1、 Jin, Yi,Li, Hui-Yuan,Lin, Li-Ping,Tan, Jinzhi,Ding, Jian,Luo, Xiaomin,Long, Ya-Qiu. "Synthesis and antitumor evaluation of novel 5-substituted-4-hydroxy-8- nitroquinazolines as EGFR signaling-targeted inhibitors". . p. 5613 - 5622. Retrieved 2007/10/03.