7463-35-6

Basic information

• Product Name: 3-CHLORO-2-METHYLACETANILIDE
• Synonyms: 3'-CHLORO-O-ACETOTOLUIDIDE;3-CHLORO-2-METHYL-N-ACETYLANILINE;3'-CHLORO-2'-METHYLACETANILIDE;3-CHLORO-2-METHYLACETANILIDE;N-(3-chloro-2-methylphenyl)acetamide;3'-Chloro-2'-methylacetanilide,98%;N-(2-Methyl-3-chlorophenyl)acetamide;N-(3-chloro-2-methyl-phenyl)ethanamide
• CAS NO: 7463-35-6
• Molecular Formula: C₉H₁₀ClNO
• Molecular Weight: 183.63
• EINECS: 231-254-2
• Product Categories: Anilines, Amides & Amines;Chlorine Compounds
• Mol File: 7463-35-6.mol
• Article Data: 23

Chemical Properties

• Melting Point: 155-157°C
• Boiling Point: 317.2 °C at 760 mmHg
• Flash Point: 145.7 °C
• Appearance: /
• Density: 1.218 g/cm³
• Vapor Pressure: 0.00039mmHg at 25°C
• Refractive Index: 1.581
• CAS DataBase Reference: 3-CHLORO-2-METHYLACETANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-2-METHYLACETANILIDE(7463-35-6)
• EPA Substance Registry System: 3-CHLORO-2-METHYLACETANILIDE(7463-35-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 7463-35-6(Hazardous Substances Data)

Usage

General Description

3-Chloro-2-methylacetanilide is a chemical compound that belongs to the class of acetanilide derivatives. It is a white, crystalline solid with a molecular formula C9H10ClNO. 3-CHLORO-2-METHYLACETANILIDE is commonly used as an intermediate in the manufacturing of pharmaceuticals, dyes, and pesticides. It has analgesic and antipyretic properties, and has been studied for its potential use in pain relief and fever reduction. Additionally, 3-Chloro-2-methylacetanilide has been found to have antibacterial and antifungal activity, making it a potential candidate for the development of new antimicrobial agents. However, its use is regulated and controlled due to its potential toxicity and environmental impact.

InChI:InChI=1/C9H10ClNO/c1-6-8(10)4-3-5-9(6)11-7(2)12/h3-5H,1-2H3,(H,11,12)

Upstream product

• 6259-40-1 3-chloro-2-methyl-aniline; hydrochloride 
• 108-24-7 acetic anhydride 
• 87-60-5 3-chloro-2-methylbenzenamine 
• 64-19-7 acetic acid 
• 127-19-5 N,N-dimethyl acetamide 
• 88-72-2 1-methyl-2-nitrobenzene 
• 83-42-1 6-chloro-2-nitrotoluene 

Downstream Products

• 72290-20-1 6-amino-2-chloro-toluene-3-sulfonic acid amide 
• 51123-58-1 acetic acid-(3-chloro-2-methyl-6-nitro-anilide) 
• 75570-95-5 acetic acid-(3,4-dichloro-2-methyl-anilide) 
• 125328-80-5 N-(4-bromo-3-chloro-2-methylphenyl)acetamide 
• 99585-95-2 acetic acid-(3,6-dichloro-2-methyl-anilide) 
• 19407-42-2 2-(acetylamino)-6-chlorobenzoic acid 
• 131923-69-8 2,7-dichloro- 8-methyl-3-formylquinoline 
• 97329-43-6 1-bromo-2-chloro-3-methyl-benzene 
• 1044256-89-4 1-bromo-3-(bromomethyl)-2-chlorobenzene 
• 959926-21-7 4-bromo-3-cyclopropyl-2-methylacetanilide 
• 3030-19-1 2-amino-5-bromo-6-chlorobenzoic acid 
• 125328-77-0 N-acetyl-5-bromo-6-chloroanthranilic acid 
• 153248-52-3 5-bromo-4-chloro-indol-3-yl-(5-acetamido-3,5-dideoxy-α-D-glycero-D-galacto-2-nonulopyranosylonic acid) 
• 125328-84-9 (5-Bromo-4-chloro-indol-3-yl)-β-L-fucopyranoside 

Relevant articles and documents

Chemoselective reduction of nitroarenes, N-acetylation of arylamines, and one-pot reductive acetylation of nitroarenes using carbon-supported palladium catalytic system in water

Developing and/or modifying fundamental chemical reactions using chemical industry-favorite heterogeneous recoverable catalytic systems in the water solvent is very important. In this paper, we developed convenient, green, and efficient approaches for the chemoselective reduction of nitroarenes, N-acetylation of arylamines, and one-pot reductive acetylation of nitroarenes in the presence of the recoverable heterogeneous carbon-supported palladium (Pd/C) catalytic system in water. The utilize of the simple, effective, and recoverable catalyst and also using of water as an entirely green solvent along with relatively short reaction times and good-to-excellent yields of the desired products are some of the noticeable features of the presented synthetic protocols. Graphic abstract: [Figure not available: see fulltext.].

Anti-malarial, cytotoxicity and molecular docking studies of quinolinyl chalcones as potential anti-malarial agent

Abstract: The quinolinyl chalcones series (A1–A14) were screened for antimalarial activity. According to in vitro antimalarial studies, many quinolinyl chalcones are potentially active against CQ-sensitive and resistance P. falciparum strains with no toxicity against Vero cell lines. The most active quinolinyl chalcones A4 (with IC50 0.031?μM) made a stable A4–heme complex with ??25?kcal/mole binding energy and also showed strong π–π interaction at 3.5??. Thus, the stable A4–heme complex formation suggested that these quinolinyl chalcones act as a blocker for heme polymerization. The docking results of quinolinyl chalcones with Pf-DHFR showed that the halogenated benzene part of quinolinyl chalcones made strong interaction with Pf-DHFR as compared to quinoline part. A strong A4–Pf-DHFR complex was formed with low binding energy (??11.04?kcal/mole). The ADMET properties of quinolinyl chalcones were also studied. The in vivo antimalarial studies also confirmed the A4 as an active antimalarial agent. Graphical abstract: [Figure not available: see fulltext.].

Ni2B@Cu2O and Ni2B@CuCl2: two new simple and efficient nanocatalysts for?the green one-pot reductive acetylation of nitroarenes and direct N-acetylation of arylamines using solvent-free mechanochemical grinding

Abstract: Ni2B@Cu2O and Ni2B@CuCl2 are introduced as simple and efficient earth-abundant transition-metal-based nanocomposites for the?green one-pot reductive acetylation of aromatic nitro compounds and direct N-acetylation of arylamines using a solvent-free mechanochemical grinding technique. The designed Ni2B-based nanocomposites were characterized by Fourier-transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD) analysis, and scanning electron microscopy (SEM) with energy-dispersive X-ray (EDX) spectroscopy. Notable advantages of these methods include broad substrate scope, use of a solvent-free mechanochemical grinding technique, implementation of earth-abundant transition-metal-based nanocomposites as simple and practical catalysts, and short reaction time and high yield at ambient condition. The mentioned methods can also be successfully applied for the?synthesis of a broad range of other amides (especially substituted acetamides) using green chemistry protocols. Also, the recoverability and reusability of the mentioned new nanocomposites were investigated. Graphical abstract: [Figure not available: see fulltext.].