N-(tert-butyl)-N-(4-fluorobenzyl)amine

Base Information

• Chemical Name: N-(tert-butyl)-N-(4-fluorobenzyl)amine
• CAS No.: 125640-89-3
• Molecular Formula: C11H16FN
• Molecular Weight: 181.253
• Hs Code.: 2921499090
• Mol file: 125640-89-3.mol

Synonyms:N-(tert-butyl)-N-(4-fluorobenzyl)amine;AKOS BBV-007448;N-(4-FLUOROPHENYLMETHYL)TERT-BUTYLAMINE;UKRORGSYN-BB BBV-007448;N-tert-Butyl-4-fluorobenzylaMine, 97%

Chemical Property of N-(tert-butyl)-N-(4-fluorobenzyl)amine

Chemical Property:

• PSA: 12.03000
• LogP: 3.10470

Purity/Quality:

99% ^*data from raw suppliers

N-(4-Fluorophenylmethyl)tert-butylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(tert-butyl)-N-(4-fluorobenzyl)amine

There total 4 articles about N-(tert-butyl)-N-(4-fluorobenzyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

4-fluorobenzaldehyde (459-57-4) + tert-butylamine (75-64-9) → N-(4-fluorobenzyl)-tert-butylamine (125640-89-3)

Guidance literature:

With carbon monoxide; 5% rhodium-on-charcoal; In tetrahydrofuran; at 160 ℃; for 20h; under 38002.6 Torr; Autoclave;

DOI:10.1002/cctc.201500493

Reference yield: 64.0%

tert-butylamine (75-64-9) + 4-Fluorobenzyl bromide (459-46-1) → N-(4-fluorobenzyl)-tert-butylamine (125640-89-3)

Guidance literature:

With sodium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 65 ℃; for 4h; Inert atmosphere;

DOI:10.1002/chem.201404990

Reference yield:

4-fluorobenzaldehyde (459-57-4) → N-(4-fluorobenzyl)-tert-butylamine (125640-89-3)

Guidance literature:

Multi-step reaction with 2 steps

1: titanium tetrachloride / diethyl ether; toluene / 0.25 h / 0 °C / Glovebox; Inert atmosphere; Schlenk technique

2: tris(2,6-difluorophenyl)borane triethylphosphine oxide; hydrogen / benzene / 3000.3 Torr / Glovebox; Inert atmosphere; Schlenk technique

With hydrogen; titanium tetrachloride; tris(2,6-difluorophenyl)borane triethylphosphine oxide; In diethyl ether; toluene; benzene;

DOI:10.1002/chem.201600716

upstream raw materials:

tert-butylamine

4-Fluorobenzyl bromide

4-fluorobenzaldehyde

N-tert-butyl-1-(4-fluorophenyl)methanimine

Downstream raw materials:

N-tert-butyl-1-(4-fluorophenyl)methanimine

C₁₅H₂₀FNO₂

Refernces

• 1、 Crowley, Daniel C.,Brouder, Thomas A.,Kearney, Aoife M.,Lynch, Denis,Ford, Alan,Collins, Stuart G.,Maguire, Anita R.. "Exploiting Continuous Processing for Challenging Diazo Transfer and Telescoped Copper-Catalyzed Asymmetric Transformations". . p. 13955 - 13982. Retrieved 2021/09/02.
• 2、 Yuan, Li,Jiang, Sheng-Ming,Li, Zeng-Zeng,Zhu, Yong,Yu, Jian,Li, Lan,Li, Ming-Zhu,Tang, Shi,Sheng, Rui-Rong. "Photocatalyzed cascade Meerwein addition/cyclization of: N -benzylacrylamides toward azaspirocycles". supporting information. p. 2406 - 2410. Retrieved 2018/04/12.