5-AMINO-2-METHOXY-BENZOIC ACID METHYL ESTER HYDROCHLORIDE

Base Information

• Chemical Name: 5-AMINO-2-METHOXY-BENZOIC ACID METHYL ESTER HYDROCHLORIDE
• CAS No.: 99450-55-2
• Molecular Formula: C9H12ClNO3
• Molecular Weight: 217.652
• Hs Code.: 2922509090
• Mol file: 99450-55-2.mol

Synonyms:5-AMINO-2-METHOXY-BENZOIC ACID METHYL ESTER HYDROCHLORIDE;Methyl 5-amino-2-methoxybenzoate hydrochloride

Chemical Property of 5-AMINO-2-METHOXY-BENZOIC ACID METHYL ESTER HYDROCHLORIDE

Chemical Property:

• PSA: 61.55000
• LogP: 2.44720

Purity/Quality:

97% ^*data from raw suppliers

5-Amino-2-methoxy-benzoicacidmethylesterhydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Amino-2-methoxy-benzoic acid methyl ester hydrochloride is used as a reactant in the preparation of novel 4,6-disubstituted aminopyrimidine derivatives as CDK9 inhibitors.

Technology Process of 5-AMINO-2-METHOXY-BENZOIC ACID METHYL ESTER HYDROCHLORIDE

There total 4 articles about 5-AMINO-2-METHOXY-BENZOIC ACID METHYL ESTER HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-methoxy-5-nitrobenzoate (34841-11-7) → 4-methoxy-3-methoxycarbonyl-phenyl-ammonium chloride (99450-55-2)

Guidance literature:

methyl 2-methoxy-5-nitrobenzoate; With tin(II) chloride dihdyrate; In methanol; for 24h; Reflux;

With hydrogenchloride; In ethyl acetate; at 0 ℃; for 0.5h;

Reference yield:

2-methoxy-5-nitro-benzoic acid sodium salt → 4-methoxy-3-methoxycarbonyl-phenyl-ammonium chloride (99450-55-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride / 0 °C

1.2: Reflux

2.1: tin(II) chloride dihdyrate / methanol / 24 h / Reflux

2.2: 0.5 h / 0 °C

With thionyl chloride; tin(II) chloride dihdyrate; In methanol;

Reference yield:

2-chloro-5-nitrobenzoic acid (2516-96-3) → 4-methoxy-3-methoxycarbonyl-phenyl-ammonium chloride (99450-55-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium / 72 h / Reflux

2.1: thionyl chloride / 0 °C

2.2: Reflux

3.1: tin(II) chloride dihdyrate / methanol / 24 h / Reflux

3.2: 0.5 h / 0 °C

With thionyl chloride; tin(II) chloride dihdyrate; sodium; In methanol;

upstream raw materials:

methyl 2-methoxy-5-nitrobenzoate

2-chloro-5-nitrobenzoic acid

Downstream raw materials:

N-benzyl-2-methoxy-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)benzamide

(2-methoxy-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)phenyl)methanol

2-methoxy-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)-N-methylbenzamide

2-methoxy-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)-N-(pyridin-4-ylmethyl)benzamide