2-methoxy-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)-N-(pyridin-4-ylmethyl)benzamide

Base Information

• Chemical Name: 2-methoxy-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)-N-(pyridin-4-ylmethyl)benzamide
• CAS No.: 1569982-62-2
• Molecular Formula: C₂₅H₂₃N₅O₃
• Molecular Weight: 441.489
• Mol file: 1569982-62-2.mol

Synonyms:2-methoxy-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)-N-(pyridin-4-ylmethyl)benzamide

Chemical Property of 2-methoxy-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)-N-(pyridin-4-ylmethyl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methoxy-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)-N-(pyridin-4-ylmethyl)benzamide

There total 7 articles about 2-methoxy-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)-N-(pyridin-4-ylmethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

4-(aminomethyl)pyridine (3731-53-1) + (4-methoxy-3-methoxycarbonyl-phenyl)-[6-(2-methoxy-phenyl)-pyrimidin-4-yl]-ammonium chloride (1569986-04-4) → 2-methoxy-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)-N-(pyridin-4-ylmethyl)benzamide (1569982-62-2)

Guidance literature:

at 100 ℃; for 36h;

Reference yield:

2-Methoxyphenylboronic acid (5720-06-9) → 2-methoxy-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)-N-(pyridin-4-ylmethyl)benzamide (1569982-62-2)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,2-dimethoxyethane / 2 h / Inert atmosphere; Reflux

2: tert-butyl alcohol / 6 h / Reflux

3: 36 h / 100 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; tert-butyl alcohol;

Reference yield:

2-methoxy-5-nitro-benzoic acid sodium salt → 2-methoxy-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)-N-(pyridin-4-ylmethyl)benzamide (1569982-62-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: thionyl chloride / 0 °C

1.2: Reflux

2.1: tin(II) chloride dihdyrate / methanol / 24 h / Reflux

2.2: 0.5 h / 0 °C

3.1: tert-butyl alcohol / 6 h / Reflux

4.1: 36 h / 100 °C

With thionyl chloride; tin(II) chloride dihdyrate; In methanol; tert-butyl alcohol;

upstream raw materials:

4-(aminomethyl)pyridine

(4-methoxy-3-methoxycarbonyl-phenyl)-[6-(2-methoxy-phenyl)-pyrimidin-4-yl]-ammonium chloride

4-chloro-6-(2-methoxy-phenyl)-pyrimidine

2-Methoxyphenylboronic acid