7-Chloro-2-chloroMethyl-1H-quinazolin-4-one

Base Information

• Chemical Name: 7-Chloro-2-chloroMethyl-1H-quinazolin-4-one
• CAS No.: 730951-40-3
• Molecular Formula: C9H6Cl2N2O
• Molecular Weight: 229.06274
• Hs Code.: 2933990090
• Mol file: 730951-40-3.mol

Synonyms:7-Chloro-2-chloroMethyl-1H-quinazolin-4-one;7-chloro-2-(chloromethyl)-4(3H)-Quinazolinone

Chemical Property of 7-Chloro-2-chloroMethyl-1H-quinazolin-4-one

Chemical Property:

• PSA: 46.01000
• LogP: 2.72760

Purity/Quality:

NLT 98% ^*data from raw suppliers

7-Chloro-2-(chloromethyl)quinazolin-4(3H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Chloro-2-chloroMethyl-1H-quinazolin-4-one

There total 4 articles about 7-Chloro-2-chloroMethyl-1H-quinazolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

chloroacetonitrile (107-14-2) + 2-Amino-4-chlorobenzoic acid (89-77-0) → 7-chloro-2-(chloromethyl)quinazolin-4(3H)-one (730951-40-3)

Guidance literature:

chloroacetonitrile; With sodium; In methanol; at 25 ℃; for 0.666667h; Inert atmosphere;

2-Amino-4-chlorobenzoic acid; In methanol; at 25 ℃; for 4h; Inert atmosphere;

DOI:10.3390/molecules15129473

Reference yield: 71.0%

2-chloro-N-(5-chloro-2-cyanophenyl)acetamide (189083-68-9) → 7-chloro-2-(chloromethyl)quinazolin-4(3H)-one (730951-40-3)

Guidance literature:

With potassium carbonate; In water; acetone; at 70 ℃; for 1.5h; Microwave irradiation;

DOI:10.3390/molecules15052949

Reference yield:

2-amino-4-chloro-benzoic acid methyl ester (5900-58-3) + chloroacetonitrile (107-14-2) → 7-chloro-2-(chloromethyl)quinazolin-4(3H)-one (730951-40-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 50 ℃;

upstream raw materials:

2-chloro-N-(5-chloro-2-cyanophenyl)acetamide

chloroacetonitrile

2-Amino-4-chlorobenzoic acid

2-amino-4-chloro-benzoic acid methyl ester

Downstream raw materials:

3,6-dichloro-8-(2-hydroxybenzoyl)-11H-pyrido[2,1-b]quinazolin-11-one