2H-Benzo[a]quinolizin-2-ol, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (2R,3S,11bS)-

Base Information

Chemical Name:2H-Benzo[a]quinolizin-2-ol, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (2R,3S,11bS)-
CAS No.:924854-62-6
Molecular Formula:C19H29NO3
Molecular Weight:319.44
Hs Code.:2933990090
Mol file:924854-62-6.mol

Synonyms:2H-Benzo[a]quinolizin-2-ol, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (2R,3S,11bS)-

Suppliers and Price of 2H-Benzo[a]quinolizin-2-ol, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (2R,3S,11bS)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(2R,3S,11bS)-Dihydrotetrabenazine
100mg
$ 1540.00

Crysdot
(2R,3S,11bS)-3-Isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-ol 96%
1g
$ 1353.00

American Custom Chemicals Corporation
2H-BENZO[A]QUINOLIZIN-2-OL, 1,3,4,6,7,11B-HEXAHYDRO-9,10-DIMETHOXY-3-(2-METHYLPROPYL)-, (2R,3S,11BS)- 95.00%
5MG
$ 495.46

Alichem
(2R,3S,11bS)-3-Isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-ol
1g
$ 1170.58

Total 9 raw suppliers

Chemical Property of 2H-Benzo[a]quinolizin-2-ol, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (2R,3S,11bS)-

Chemical Property:

Boiling Point:457.8±45.0 °C(Predicted)
PKA:14.75±0.40(Predicted)
PSA：41.93000
Density:1.13±0.1 g/cm3(Predicted)
LogP:2.96780
Storage Temp.:2-8°C

Purity/Quality:

98% ^*data from raw suppliers

(2R,3S,11bS)-Dihydrotetrabenazine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (2R,3S,11bS)-Dihydrotetrabenazine is an inhibitor of vascular monoamine transporter 2 (VMAT2).

Technology Process of 2H-Benzo[a]quinolizin-2-ol, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (2R,3S,11bS)-

There total 5 articles about 2H-Benzo[a]quinolizin-2-ol, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (2R,3S,11bS)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 718635-93-9,1381929-92-5
tetrabenazine

: 924854-62-6
(2R,3S,11bS)-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol

: 924854-60-4
(+)-β-DHTBZ

Guidance literature:: With L-Selectride; In tetrahydrofuran; ethanethiol; at 0 ℃; for 1h; Product distribution / selectivity;

Reference yield:

: 58-46-8,1381929-92-5
(3R^*,11bR^*)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo quinolizin-2-one

: 924854-62-6
(2R,3S,11bS)-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol

: 924854-60-4
(+)-β-DHTBZ

Guidance literature:: With L-Selectride; In tetrahydrofuran; ethanol; at 0 ℃; for 1h; Product distribution / selectivity;

Reference yield:

: 1026016-84-1,1381929-92-5
(3S,11bS)-tetrabenazine

: 924854-62-6
(2R,3S,11bS)-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol

Guidance literature:: (3S,11bS)-tetrabenazine; With ethanol; L-Selectride; In tetrahydrofuran; at 0 ℃; for 0.666667h;

With methanesulfonic acid; In ethanol; at 20 ℃;

With ammonium hydroxide; diastereoselective reaction;
DOI:10.1016/j.ejmech.2011.02.046