Boc-Lys-OtBu.HCl

Base Information

• Chemical Name: Boc-Lys-OtBu.HCl
• CAS No.: 7750-42-7
• Molecular Formula: C15H30N2O4
• Molecular Weight: 302.414
• Mol file: 7750-42-7.mol

Synonyms:(S)-tert-Butyl 6-amino-2-((tert-butoxycarbonyl)amino)hexanoate

Chemical Property of Boc-Lys-OtBu.HCl

Chemical Property:

• Boiling Point: 406.7±40.0 °C(Predicted)
• PKA: 11.16±0.46(Predicted)
• PSA: 90.65000
• Density: 1.021±0.06 g/cm3(Predicted)
• LogP: 3.44160
• Storage Temp.: 2-8°C(protect from light)
• Solubility.: Chloroform (Sparingly), Methanol (Sparingly)

Purity/Quality:

98% ^*data from raw suppliers

(S)-tert-Butyl6-amino-2-((tert-butoxycarbonyl)amino)hexanoate 90% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-Boc-Lysine Tert-butyl Ester is used in preparation of Tetrahydroisoquinoline derivatives as blood coagulation factor inhibitors useful in the treatment of thromboembolic disorders.

Technology Process of Boc-Lys-OtBu.HCl

There total 13 articles about Boc-Lys-OtBu.HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N2-[(1,1-dimethylethoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-L-lysine 1,1-dimethylethyl ester (135727-85-4) → tert-butyl N-tert-butyloxycarbonyl-L-lysinate (7750-42-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; for 20h; under 760.051 Torr; Inert atmosphere;

DOI:10.1002/anie.200805420

Reference yield: 88.0%

tert-butyl (Z)-N2-(tert-butoxycarbonyl)-N6-(2-oxo-2-phenylethylidene)-L-lysinate → tert-butyl N-tert-butyloxycarbonyl-L-lysinate (7750-42-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 3h;

DOI:10.1002/anie.201913620

Reference yield: 84.0%

5-(S)-(tert-butoxycarbonyl)-5-[(tert-butoxycarbonyl)amino]pentylammonium chloride (7750-45-0) → tert-butyl N-tert-butyloxycarbonyl-L-lysinate (7750-42-7)

Guidance literature:

With sodium hydrogencarbonate; In chloroform; water;

DOI:10.1021/jm980389p

upstream raw materials:

N²-[(1,1-dimethylethoxy)carbonyl]-N⁶-[(phenylmethoxy)carbonyl]-L-lysine 1,1-dimethylethyl ester

5-(S)-(tert-butoxycarbonyl)-5-[(tert-butoxycarbonyl)amino]pentylammonium chloride

Boc-Lys-OH

tert-butyl alcohol

Downstream raw materials:

(S)-tert-butyl 6-((R)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-(benzyloxy)-5-oxopentanamido)-2-((tert-butoxycarbonyl)amino)hexanoate

tert-butyl N₂-(tert-butoxycarbonyl)-N₆-((S)-(-)-2-tert-butoxycarbonylamino-3-(tritylthio)-propanoyl)lysinate

tert-butyl N₂-(tert-butoxycarbonyl)-N₆-((R)-(+)-2-tert-butoxycarbonylamino-3-(tritylthio)-propanoyl)lysinate

Refernces

• 1、 Tsutsumi, Hiroshi,Tanaka, Kunifumi,Chia, Jyh Yea,Mihara, Hisakazu. "Short self-assembling peptides with a urea bond: A new type of supramolecular peptide hydrogel materials". . . Retrieved 2020/12/01.
• 2、 -. "METHODS OF PREPARING N6-((2-AZIDOETHOXY)CARBONYL)LYSINE". Paragraph 0436; 0439-0441. . Retrieved 2021/07/02.