135727-85-4

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 5978-22-3 N(ε)-benzoyloxycarbonyl-L-lysine tert-butyl ester hydrochloride 
• 507-19-7 t-butyl bromide 
• 2389-45-9 Boc-Lys(Z)-OH 
• 1155-64-2 N₆-[(benzyloxy)carbonyl]-L-lysine 
• 13734-28-6 Boc-Lys-OH 
• 501-53-1 benzyl chloroformate 
• 75-65-0 tert-butyl alcohol 
• 71432-55-8 2-tert-butyl-1,3-diisopropylisourea 
• 63628-63-7 Nε-benzyloxycarbonyl-L-lysine tert-butyl ester 
• 98946-18-0 tert-Butyl 2,2,2-trichloroacetimidate 
• 86060-82-4 Fmoc-Lys(Z)-OH 

Downstream Products

• 7750-42-7 tert-butyl N-tert-butyloxycarbonyl-L-lysinate 
• 63628-63-7 Nε-benzyloxycarbonyl-L-lysine tert-butyl ester 
• 1027089-85-5 (S)-3-Methyl-2-{(S)-2-[(S)-6-nitro-2-(2-trimethylsilanyl-ethoxycarbonylamino)-hexanoylamino]-3-phenyl-propionylamino}-butyric acid methyl ester 
• 205379-08-4 N^α,N^α-bis[(tert-butyloxycarbonyl)methyl]-L-lysine tert-butyl ester 
• 189280-04-4 (2S,9R)-7-Benzyl-2-[(tert-butoxycarbonyl)amino]-10-cyano-9-hydroxy-7-azadecanoic Acid tert-Butyl Ester 
• 189279-99-0 (S)-6-[Benzyl-((S)-3-chloro-2-hydroxy-propyl)-amino]-2-tert-butoxycarbonylamino-hexanoic acid tert-butyl ester 
• 189279-95-6 (S)-t-Boc-Lys(Bz)-O-t-Bu 
• 214051-65-7 (2S,9S)-2-[(tert-Butoxycarbonyl)amino]-7-(carbobenzyloxy)-10-cyano-9-hydroxy-7-azadecanoic Acid tert-Butyl Ester 
• 214051-64-6 (S)-6-[Benzyloxycarbonyl-((R)-3-cyano-2-hydroxy-propyl)-amino]-2-tert-butoxycarbonylamino-hexanoic acid tert-butyl ester 
• 214051-63-5 (2S,9R)-2-[(tert-Butoxycarbonyl)amino]-7-(carbobenzyloxy)-10-chloro-9-hydroxy-7-azadecanoic Acid tert-Butyl Ester 
• 214051-62-4 (2S,9S)-2-[(tert-Butoxycarbonyl)amino]-7-(carbobenzyloxy)-10-chloro-9-hydroxy-7-azadecanoic Acid tert-Butyl Ester 
• 214051-69-1 (2S,9S)-11-[(Benzyloxycarbonyl)amino]-2-[(tert-butoxycarbonyl)amino]-9-hydroxy-7-(carbobenzyloxy)-7-azaundecanoic Acid tert-Butyl Ester 
• 189280-15-7 tert-butyl(2S,9R)-11-[(benzyloxycarbonyl)amino]-2-[(tert-butoxycarbonyl)amino]-9-hydroxy-7-(benzyloxycarbonyl)-7-azaundecanoate 
• 1167421-25-1 (2S)-2-amino-6-{[(2-azidoethoxy)carbonyl]amino}hexanoic acid 

Relevant academic research and scientific papers

Short self-assembling peptides with a urea bond: A new type of supramolecular peptide hydrogel materials

There is an increasing need to develop short self-assembling peptides (SAPs) that can form hydrogels for cell engineering and biomedical applications. In this study, we proposed new short self-assembling peptides with a symmetric structure via a urea bond

SWCNT-porphyrin nano-hybrids selectively activated by ultrasound: an interesting model for sonodynamic applications

Sonodynamic therapy (SDT) is an innovative anticancer approach, based on the excitation of a given molecule (usually a porphyrin) by inertial acoustic cavitation that leads to cell deathviathe production of reactive oxygen species (ROS). This study aims t

Synthesis and evaluation of macrocyclic amino acid derivatives for tumor imaging by gallium-68 positron emission tomography

68Ga PET imaging in clinical oncology represents a notable development because the availability of 68Ga is not dependent on a cyclotron. Furthermore, labeled amino acid derivatives have been proven to be useful for the imaging many t

Biofunctional supramolecular hydrogels fabricated from a short self-assembling peptide modified with bioactive sequences for the 3D culture of breast cancer MCF-7 cells

Self-assembling peptides are a type of molecule with promise as scaffold materials for cancer cell engineering. We have reported a short self-assembling peptide, (FFiK)2, that had a symmetric structure connected via a urea bond. In this study, we functionalized (FFiK)2 by conjugation with various bioactive sequences for the 3D culture of cancer cells. Four sequences, RGDS and PHSRN derived from fibronectin and AG73 and C16 derived from laminin, were selected as bioactive sequences to promote cell adhesion, proliferation or migration. (FFiK)2, and its derivatives could co-assemble into supramolecular nanofibers displaying bioactive sequences and form hydrogels. MCF-7 cells were encapsulated in functionalized peptide hydrogels without significant cytotoxicity. Encapsulated MCF-7 cells proliferated under 3D culture conditions. MCF-7 cells proliferated with spheroid formation in hydrogels that displayed RGDS or PHSRN sequences, which will be able to be applied to drug screening targeting cancer stem cells. On the other hand, since MCF-7 cells migrated in a 3D hydrogel that displayed AG73, we could construct the metastatic model of breast cancer cells, which is helpful for the elucidation of breast cancer cells and drug screening against cancer cells under metastatic state. Therefore, functionalized (FFiK)2 hydrogels with various bioactive sequences can be used to regulate cancer cell function for tumor engineering and drug screening.

Synthesis of the unnatural amino acid Nα-Nε-(ferrocene-1-acetyl)-l-lysine: A novel organometallic nuclease

The synthesis of a new unnatural amino acid, Nα-Nε-(ferrocene-1-acetyl)-l-lysine, was achieved by coupling a ferroceneacetic acid molecule onto the side chain amine of a lysine. The structure of the compound provides options for inco

Analysis of Advanced Glycation Endproducts in Rat Tail Collagen and Correlation to Tendon Stiffening

Methylglyoxal is a major 1,2-dicarbonyl compound in vivo and leads to nonenzymatic protein modifications, known as advanced glycation endproducts. Especially long-lived proteins like collagen are prone to changes of the mechanical or biological function,

METHODS OF PREPARING N6-((2-AZIDOETHOXY)CARBONYL)LYSINE

Disclosed herein are methods of preparing N6-((2-azidoethoxy)carbonyl)lysine, N6-((2-azidoethoxy)carbonyl)-L-lysine, and N6-((2-azidoethoxy)carbonyl)-D-lysine. Also disclosed herein are the compounds tert-butyl N2-(tert-butoxycarbonyl)-N6-((2-chloroethoxy)carbonyl)-L-lysinate and tertbutyl N6-((2-azidoethoxy)carbonyl)-N2-(tert-butoxycarbonyl)-L-lysinate, and uses thereof.

Non-natural amino acid and application thereof in protein site-specific modification and protein interaction

The invention relates to a non-natural amino acid compound represented by a general formula (I) and a preparation method thereof, and applications of the non-natural amino acid compound in fixed-pointmodification of bio-macro-molecular proteins, protein i

Antitumor agents 7. Synthesis, antiproliferative activity and molecular modeling of new L-lysine-conjugated pyridophenoxazinones as potent DNA-binding ligands and topoisomerase IIα inhibitors

A series of L-lysine-conjugated pyridophenoxazinones 2–5 and 2′-5′ were designed and synthesized for developing compounds with multimodal anticancer potentialities. All compounds inhibited the proliferation of a panel of human liquid and solid neoplastic

Optimized reaction pair of the Cyshis tag and Ni(II)-Nta probe for highly selective chemical labeling of membrane proteins

Chemical labeling of proteins with synthetic molecular probes offers the possibility to probe the functions of proteins of interest in living cells. However, the methods for covalently labeling targeted proteins using complementary peptide tag-probe pairs are still limited, irrespective of the versatility of such pairs in biological research. Herein, we report the new CysHis tag-Ni(II) probe pair for the specific covalent labeling of proteins. A broad-range evaluation of the reactivity profiles of the probe and the CysHis peptide tag afforded a tag-probe pair with an optimized and high labeling selectivity and reactivity. In particular, the labeling specificity of this pair was notably improved compared to the previously reported one. This pair was successfully utilized for the fluorescence imaging of membrane proteins on the surfaces of living cells, demonstrating its potential utility in biological research.