13-{[(3-t-Boc)-2,2-dimethyl-4S-phenyl-1,3-oxazolidin-5R-yl]formyl}-7-O-(2,2,2-trichloroethyl)oxy]carbonyl) Baccatin III

Base Information

Chemical Name:13-{[(3-t-Boc)-2,2-dimethyl-4S-phenyl-1,3-oxazolidin-5R-yl]formyl}-7-O-(2,2,2-trichloroethyl)oxy]carbonyl) Baccatin III
CAS No.:143527-73-5
Molecular Formula:C51H60Cl3NO17
Molecular Weight:1065.39
Hs Code.:
Mol file:143527-73-5.mol

Synonyms:13-{[(3-t-Boc)-2,2-dimethyl-4S-phenyl-1,3-oxazolidin-5R-yl]formyl}-7-O-(2,2,2-trichloroethyl)oxy]carbonyl) Baccatin III;(4S,5R)-2,2-DiMethyl-4-phenyl-3,5-oxazolidinedicarboxylic Acid 5-[(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-12-(benzoyl

Suppliers and Price of 13-{[(3-t-Boc)-2,2-dimethyl-4S-phenyl-1,3-oxazolidin-5R-yl]formyl}-7-O-(2,2,2-trichloroethyl)oxy]carbonyl) Baccatin III

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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TRC
13-{[(3-t-Boc)-2,2-dimethyl-4S-phenyl-1,3-oxazolidin-5R-yl]formyl}-7-O-(2,2,2-trichloroethyl)oxy]carbonyl)BaccatinIII
5mg
$ 165.00

Total 2 raw suppliers

Chemical Property of 13-{[(3-t-Boc)-2,2-dimethyl-4S-phenyl-1,3-oxazolidin-5R-yl]formyl}-7-O-(2,2,2-trichloroethyl)oxy]carbonyl) Baccatin III

Chemical Property:

PSA：226.03000
LogP:7.78580
Solubility.:Chloroform, Ethyl Acetate

Purity/Quality:

> 98% ^*data from raw suppliers

13-{[(3-t-Boc)-2,2-dimethyl-4S-phenyl-1,3-oxazolidin-5R-yl]formyl}-7-O-(2,2,2-trichloroethyl)oxy]carbonyl)BaccatinIII ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 13-{[(3-t-Boc)-2,2-dimethyl-4S-phenyl-1,3-oxazolidin-5R-yl]formyl}-7-O-(2,2,2-trichloroethyl)oxy]carbonyl) Baccatin III

There total 11 articles about 13-{[(3-t-Boc)-2,2-dimethyl-4S-phenyl-1,3-oxazolidin-5R-yl]formyl}-7-O-(2,2,2-trichloroethyl)oxy]carbonyl) Baccatin III which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 103150-33-0
7-(2,2,2-trichloroethyloxycarbonyl)baccatin III

: 143615-03-6,143527-70-2
(4S,5R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid

: 143527-73-5
C₅₁H₆₀Cl₃NO₁₇

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In toluene; at 80 ℃; for 2h;
DOI:10.1016/S0040-4039(00)79128-3

Reference yield:

: 144787-20-2
(2R,3S)-3-azido-2-hydroxy-benzenepropanoic acid ethyl ester

: 143527-73-5
C₅₁H₆₀Cl₃NO₁₇

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / H₂ / 10percent Pd/C / ethyl acetate / 760 Torr

2: 76 percent / NaHCO₃ / CH₂Cl₂ / 20 °C

3: 99 percent / pyridinium paratoluenesulfonate (PTSP) / toluene / 80 °C

4: 100 percent / LiOH, H₂O / ethanol / 20 °C

5: 99 percent / DCC, DMAP / toluene / 2 h / 80 °C

With dmap; lithium hydroxide; water; hydrogen; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate; toluene;
DOI:10.1016/S0040-4039(00)79128-3

Reference yield:

: 100-52-7
benzaldehyde

: 143527-73-5
C₅₁H₆₀Cl₃NO₁₇

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) Et₃N, Bu₂BOTf / 1.) CH₂Cl₂, -70 to 20 deg C, 2 h, 2.) -78 to 0 deg C, 1 h

2: 81 percent / tetrahydrofuran / 0.25 h / -75 - 15 °C

3: 99 percent / NaN₃, NH₄Cl / ethanol / 8 h / 60 °C

4: 86 percent / H₂ / 10percent Pd/C / ethyl acetate / 760 Torr

5: 76 percent / NaHCO₃ / CH₂Cl₂ / 20 °C

6: 99 percent / pyridinium paratoluenesulfonate (PTSP) / toluene / 80 °C

7: 100 percent / LiOH, H₂O / ethanol / 20 °C

8: 99 percent / DCC, DMAP / toluene / 2 h / 80 °C

With dmap; lithium hydroxide; sodium azide; di-n-butylboryl trifluoromethanesulfonate; water; hydrogen; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; ammonium chloride; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; toluene;
DOI:10.1016/S0040-4039(00)79128-3