N,4-DIHYDROXY-3-METHOXY-BENZENE CARBOXIMIDOYL CHLORIDE

Base Information

• Chemical Name: N,4-DIHYDROXY-3-METHOXY-BENZENE CARBOXIMIDOYL CHLORIDE
• CAS No.: 596095-21-5
• Molecular Formula: C8H8ClNO3
• Molecular Weight: 201.609
• Mol file: 596095-21-5.mol

Synonyms:N,4-DIHYDROXY-3-METHOXY-BENZENE CARBOXIMIDOYL CHLORIDE

Chemical Property of N,4-DIHYDROXY-3-METHOXY-BENZENE CARBOXIMIDOYL CHLORIDE

Chemical Property:

• PSA: 62.05000
• LogP: 1.77540

Purity/Quality:

N,4-DIHYDROXY-3-METHOXY-BENZENECARBOXIMIDOYLCHLORIDE 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,4-DIHYDROXY-3-METHOXY-BENZENE CARBOXIMIDOYL CHLORIDE

There total 2 articles about N,4-DIHYDROXY-3-METHOXY-BENZENE CARBOXIMIDOYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

vanillin oxime (2874-33-1) → N,4-dihydroxy-3-methoxybenzimidoyl chloride (596095-21-5)

Guidance literature:

With pyridine; N-chloro-succinimide; In tetrahydrofuran; chloroform; for 2h;

DOI:10.1016/S0960-894X(03)00130-6

Reference yield:

vanillin (121-33-5,8014-42-4) → N,4-dihydroxy-3-methoxybenzimidoyl chloride (596095-21-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; sodium acetate / methanol; water / 12 h / 20 °C

2: N-chloro-succinimide / N,N-dimethyl-formamide / 5 h / 20 °C

With N-chloro-succinimide; hydroxylamine hydrochloride; sodium acetate; In methanol; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2011.10.056

Reference yield: 50.0%

C15H9NO + N,4-dihydroxy-3-methoxybenzimidoyl chloride (596095-21-5) → 10‐{[3‐(4‐hydroxy‐3‐methoxyphenyl)‐1,2‐oxazol‐5‐yl]methyl}‐acridin‐9‐one

Guidance literature:

With triethylamine; In chloroform; at 40 - 70 ℃; for 0.416667h; Temperature; regioselective reaction; Microwave irradiation; Sealed tube;

DOI:10.1002/ardp.202000261

upstream raw materials:

vanillin oxime

vanillin

Downstream raw materials:

2-(3-(4-hydroxy-3-methoxyphenyl)-4,5-dihydroisoxazol-5-yl)acetic acid