3-amino-6-(hydroxymethyl)oxane-2,4,5-triol Hydrochloride

Base Information

• Chemical Name: 3-amino-6-(hydroxymethyl)oxane-2,4,5-triol Hydrochloride
• CAS No.: 14257-79-5
• Molecular Formula: C6H13 N O5 . Cl H
• Molecular Weight: 215.634
• European Community (EC) Number: 200-638-1
• NSC Number: 283301
• DSSTox Substance ID: DTXSID60931528
• NCI Thesaurus Code: C83732
• RXCUI: 236608
• Mol file: 14257-79-5.mol

Synonyms:3-amino-6-(hydroxymethyl)oxane-2,4,5-triol Hydrochloride;1397188-81-6;Glucosamine hydrochloride;D-Glucosamine-1-13C hydrochloride;D-Galactosamine HCl;2-[15N]amino-2-deoxy-D-galactose hydrochloride;2-Amino-2-deoxy-D-[1-13C]galactose hydrochloride;478518-54-6;14257-79-5;SCHEMBL15541837;DTXSID60931528;CCG-2258;.beta.-D-Galaltosamine hydrochloride;C(O)C1OC(O)C(N)C(O)C1O;NSC283301;AKOS009031374;NSC-283301;SB46976;.beta.-D-Galactopyranose, hydrochloride;PD056345;SY011489;Galactopyranose, hydrochloride, .beta.-D-;EN300-20118;2-Amino-2-deoxyhexopyranose--hydrogen chloride (1/1);3-amino-6-(hydroxymethyl)oxane-2,4,5-triolHydrochloride;.beta.-D-Galactopyranose, 2-amino-2-deoxy-, hydrochloride;Galactopyranose, 2-amino-2-deoxy-, hydrochloride, .beta.-D-

Chemical Property of 3-amino-6-(hydroxymethyl)oxane-2,4,5-triol Hydrochloride

Chemical Property:

• Boiling Point: 449.9°Cat760mmHg
• Flash Point: 225.9°C
• Density: 1.563g/cm³
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 1
• Exact Mass: 215.0560502
• Heavy Atom Count: 13
• Complexity: 155

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Biological Agents -> Monosaccharides and Derivatives
• Canonical SMILES: C(C1C(C(C(C(O1)O)N)O)O)O.Cl
• Recent ClinicalTrials: Effects of Oral Glucosamine on Insulin and Blood Vessel Activity in Normal and Obese People
• Recent EU Clinical Trials: Evaluation of the evolution of imaging markers of cartilage degradation in patients with knee osteoarthritis receiving DROGLICAN?: a Pilot Study
• Recent NIPH Clinical Trials: Investigation of blood kinetics at the time of ingestion of coating processed glucosamine hydrochloride

Technology Process of 3-amino-6-(hydroxymethyl)oxane-2,4,5-triol Hydrochloride

There total 5 articles about 3-amino-6-(hydroxymethyl)oxane-2,4,5-triol Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-benzyl-D-galactosamine → D-(+)-galactosamine hydrochloride (1772-03-8,4710-95-6,6730-09-2,14131-59-0,14131-62-5,14131-63-6,14131-65-8,14131-67-0,14257-79-5,19124-46-0,20706-90-5,91673-92-6)

Guidance literature:

With hydrogenchloride; hydrogen; palladium dihydroxide; In 1,4-dioxane; water; at 20 ℃; pH=1; atmospheric pressure;

DOI:10.1080/07328300500495795

Reference yield:

N-benzyl-D-tagatosylamine (887472-18-6) → D-(+)-galactosamine hydrochloride (1772-03-8,4710-95-6,6730-09-2,14131-59-0,14131-62-5,14131-63-6,14131-65-8,14131-67-0,14257-79-5,19124-46-0,20706-90-5,91673-92-6)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / methanol / 1 h / 20 °C

2: hydrogen; hydrochloric acid / palladium(II) hydroxide on carbon / dioxane; H₂O / 20 °C / pH 1 / atmospheric pressure

With hydrogenchloride; hydrogen; acetic acid; palladium dihydroxide; In 1,4-dioxane; methanol; water; 1: Heyns rearrangement;

DOI:10.1080/07328300500495795

Reference yield:

(3S,4S,5R)-2-(hydroxymethyl)tetrahydropyran-2,3,4,5-tetrol (41847-61-4) → D-(+)-galactosamine hydrochloride (1772-03-8,4710-95-6,6730-09-2,14131-59-0,14131-62-5,14131-63-6,14131-65-8,14131-67-0,14257-79-5,19124-46-0,20706-90-5,91673-92-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 40 °C

2: acetic acid / methanol / 1 h / 20 °C

3: hydrogen; hydrochloric acid / palladium(II) hydroxide on carbon / dioxane; H₂O / 20 °C / pH 1 / atmospheric pressure

With hydrogenchloride; hydrogen; acetic acid; palladium dihydroxide; In 1,4-dioxane; methanol; water; 2: Heyns rearrangement;

DOI:10.1080/07328300500495795

upstream raw materials:

allosamidin

N-benzyl-D-tagatosylamine

(3S,4S,5R)-2-(hydroxymethyl)tetrahydropyran-2,3,4,5-tetrol

Downstream raw materials:

(3aR)-3-(3,4-dichloro-phenyl)-5t-((R)-1,2-dihydroxy-ethyl)-6t-hydroxy-(3ar,6ac)-hexahydro-furo[2,3-d]imidazole-2-thione

2-deoxy-2-(bromoacetamido)-D-mannose

kifunensine

(3aR,3bS,6bR,10aR,10bS)-2,2,9,9-tetramethyl-1,3,8,10-tetraoxacyclohexa[e]cyclopenta[g]-5,6-dion-4-azaindolizidine