10.1021/acs.orglett.1c01489
The research aims to develop efficient methods for synthesizing peroxides, which are crucial in the production of biologically active natural products and potential drugs. The study focuses on the use of cobalt picolinate catalysts, prepared from commercially available picolinic acids, to catalyze the hydroperoxidation of alkenes. The process involves the use of molecular oxygen and tetramethyldisiloxane (TMDSO) to synthesize hydroperoxides in a one-step reaction. The researchers found that these catalysts are effective at low loadings, can be easily handled and stored, and can be tuned using substituted picolinic acids. The study concluded that cobalt picolinate complexes are valuable catalysts for both hydroperoxidation and hydration of alkenes, leading to the formation of 1,2-dioxolanes, which are core structures in many biologically active compounds. The research also proposed a mechanistic pathway for the formation of hydroperoxides, suggesting that the reaction proceeds via an exchange of a peroxide ligand on cobalt with isopropanol, rather than through transmetallation.
10.1016/j.ica.2020.119514
This research presents the synthesis, characterization, and crystal structure of a new Cu(II)-carboxamide complex, [Cu(L)2(H2O)].CHCl3 (1), and CuO nanoparticles (2), which were evaluated as catalysts in the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction and for their antibacterial activity. The purpose of the study was to develop green, efficient, and affordable catalysts for molecular engineering applications and to assess their potential as antibacterial agents. The carboxamide ligand N-(thiazole-2-yl) picolinamide (LH) was synthesized in the ionic liquid TBAB, and the Cu(II)-complex (1) was prepared from LH and copper(II) acetate. CuO nanoparticles (2) were obtained by thermal decomposition of (1). The study concluded that the Cu(II)-complex (1) and CuO nanoparticles (2) are effective catalysts for the CuAAC reaction under mild conditions and exhibit strong antibacterial activity comparable to penicillin. The chemicals used in the process included TBAB, picolinic acid, 2-aminothiazole, copper(II) acetate, and various other reagents for characterization and testing.
10.1016/j.bmcl.2008.08.008
The research aims to identify a series of non-imidazole histamine H3 receptor antagonists based on the (3-phenoxypropyl)amine motif, which is a common pharmacophore for H3 antagonists. The study investigates the structure-activity relationship (SAR) around the amine moiety and identifies compound 8a as a potent H3 antagonist with good pharmacokinetic properties in rats. The key chemicals used in the research include di?uoronitrobenzene, picolinic acid, and various amines for the synthesis of benzimidazole-substituted analogs. The study concludes that this series of benzimidazole-derived H3 ligands demonstrates excellent binding affinity to the H3 receptor and tolerance for different substituents on the phenyl ring, but also highlights the potential for interaction with the hERG channel, which is a common issue with this pharmacophore.
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