5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Base Information

• Chemical Name: 5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid
• CAS No.: 333761-72-1
• Molecular Formula: C15H10F3N3O3
• Molecular Weight: 337.258
• Hs Code.: 2933990090
• Mol file: 333761-72-1.mol

Synonyms:5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid;pyrazolo[1,5-a]pyrimidine-3-carboxylic acid, 5-(4-methoxyphenyl)-7-(trifluoromethyl)-;pyrazolo[1,5-a]pyrimidine-3-carboxylic acid, 5-(4-methoxyp;5-(4-methoxyphenyl)-7-(trifluoromethyl)-3-pyrazolo[1,5-a]pyrimidinecarboxylic acid;AK-968/11789325;BAS 00923937;BIM-0035012.P001;CBMicro_035006

Chemical Property of 5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Chemical Property:

• PSA: 76.72000
• LogP: 3.12190

Purity/Quality:

98%min ^*data from raw suppliers

5-(4-Methoxyphenyl)-7-(trifluoromethyl)pyrazolo-[1,5-a]pyrimidine-3-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

There total 3 articles about 5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid methyl ester (333761-74-3) → 5-(4-methoxyphenyl)-7-(trifluoromethyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (333761-72-1)

Guidance literature:

5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid methyl ester; With sodium hydroxide; ethanol; water; at 70 ℃; for 3h;

With hydrogenchloride; water; for 0.25h;

Reference yield:

1-(4-methoxyphenyl)ethanone (100-06-1) → 5-(4-methoxyphenyl)-7-(trifluoromethyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (333761-72-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium tert-butylate / toluene / 0.08 - 0.17 h / 0 °C

1.2: 16.08 - 16.17 h / 20 °C

1.3: 0.08 - 0.17 h

2.1: acetic acid / 16 h / 80 °C

3.1: sodium hydroxide; ethanol; water / 3 h / 70 °C

3.2: 0.25 h

With sodium hydroxide; ethanol; potassium tert-butylate; water; acetic acid; In toluene;

Reference yield:

4,4,4-trifluoro-1-(4-methoxyphenyl)-1,3-butanedione (15191-68-1) → 5-(4-methoxyphenyl)-7-(trifluoromethyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (333761-72-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid / 16 h / 80 °C

2.1: sodium hydroxide; ethanol; water / 3 h / 70 °C

2.2: 0.25 h

With sodium hydroxide; ethanol; water; acetic acid;

upstream raw materials:

5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid methyl ester

4,4,4-trifluoro-1-(4-methoxyphenyl)-1,3-butanedione

1-(4-methoxyphenyl)ethanone

Downstream raw materials:

C₁₅H₉ClF₃N₃O₂

2-({[5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo-[1,5-a]-pyrimidin-3-yl]carbonyl}amino)-4,5,6,7-tetrahydrobenzo[b]-thiophene-3-carboxamide

C₂₇H₂₄F₄N₄O₂

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