LEU-PRO TRIFLUOROACETATE SALT

Base Information

• Chemical Name: LEU-PRO TRIFLUOROACETATE SALT
• CAS No.: 67320-92-7
• Molecular Formula: C13H21F3N2O5
• Molecular Weight: 342.315
• Mol file: 67320-92-7.mol

Synonyms:H-LEU-PRO-OH TFA;LEU-PRO TRIFLUOROACETATE SALT;L-LEUCYL-L-PROLINE TRIFLUOROACETATE SALT;leu-pro trifluoroacetate;1-L-Leucyl-L-proline mono(trifluoroacetate)

Chemical Property of LEU-PRO TRIFLUOROACETATE SALT

Chemical Property:

• PSA: 120.93000
• LogP: 1.70690
• Storage Temp.: −20°C

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of LEU-PRO TRIFLUOROACETATE SALT

There total 7 articles about LEU-PRO TRIFLUOROACETATE SALT which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(tert-butoxycarbonyl)-L-leucyl-L-proline (64205-66-9) + trifluoroacetic acid (76-05-1) → (S)-1-((S)-2-Amino-4-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid; compound with trifluoro-acetic acid (67320-92-7)

Guidance literature:

for 0.666667h;

DOI:10.1002/kin.10034

Reference yield:

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) → (S)-1-((S)-2-Amino-4-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid; compound with trifluoro-acetic acid (67320-92-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 1-hydroxybenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide / dimethylformamide / -15 °C

1.2: 91.7 percent / N-methylmorpholine / dimethylformamide / 20 °C

2.1: 95.9 percent / aq. NaOH / methanol / 2 h / 20 °C

3.1: 100 percent / 0.67 h

With sodium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In methanol; N,N-dimethyl-formamide;

DOI:10.1002/kin.10034

Reference yield:

benzyl (2S)-1-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-4-methylpentanoyl]pyrrolidine-2-carboxylate (83610-44-0) → (S)-1-((S)-2-Amino-4-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid; compound with trifluoro-acetic acid (67320-92-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 95.9 percent / aq. NaOH / methanol / 2 h / 20 °C

2: 100 percent / 0.67 h

With sodium hydroxide; In methanol;

DOI:10.1002/kin.10034

upstream raw materials:

trifluoroacetic acid

(tert-butoxycarbonyl)-L-leucyl-L-proline

N-tert-butoxycarbonyl-L-leucine

benzyl (2S)-1-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-4-methylpentanoyl]pyrrolidine-2-carboxylate

Downstream raw materials:

Boc-Asp(OBzl)-Leu-Pro-OH

butyraldehyde

isovaleraldehyde