83610-44-0

Basic information

• Product Name: L-Proline, N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl-, phenylmethyl ester
• Synonyms: Boc-L-Leu-L-Pro-OBzl;Boc-L-Leu-L-Pro-OBn;(tert-butoxycarbonyl)leucylproline benzyl ester;Boc-Leu-Pro-OBn
• CAS NO: 83610-44-0
• Molecular Formula: C23H34N2O5
• Molecular Weight: 418.533
• Mol File: 83610-44-0.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 557.3±50.0 °C(Predicted)
• Density: 1.128±0.06 g/cm3(Predicted)
• CAS DataBase Reference: L-Proline, N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Proline, N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl-, phenylmethyl ester(83610-44-0)
• EPA Substance Registry System: L-Proline, N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl-, phenylmethyl ester(83610-44-0)

Safety Data

• Hazardous Substances Data: 83610-44-0(Hazardous Substances Data)

Upstream product

• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 16652-71-4 benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride 
• 41324-66-7 H-Pro-OBzl 
• 70533-96-9 N-tert-butoxycarbonyl-(L)-leucinamide 

Downstream Products

• 64205-66-9 (tert-butoxycarbonyl)-L-leucyl-L-proline 
• 83610-64-4 leucylproline benzyl ester 
• 89545-43-7 H-Leu-Pro-OBzl hydrochloride 
• 1222507-88-1 C₂₈H₃₈N₄O₃ 
• 83610-72-4 Boc-Ile-Leu-Pro-OBn 
• 118171-81-6 TBDMS-(2RS,4S)-Hip-(S)-Leu-(S)-Pro-OBzl 
• 118171-82-7 H-(2RS,4S)-Hip-(S)-Leu-(S)-Pro-OBzl 

Relevant articles and documents

Asymmetric Disulfanylbenzamides as Irreversible and Selective Inhibitors of Staphylococcus aureus Sortase A

Staphylococcus aureus is one of the most frequent causes of nosocomial and community-acquired infections, with drug-resistant strains being responsible for tens of thousands of deaths per year. S. aureus sortase A inhibitors are designed to interfere with

Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP

We report the systematic rational design and synthesis of new monovalent Smac mimetics that bind preferentially to the BIR2 domain of the anti-apoptotic protein XIAP. Characterization of compounds in vitro (including 9i; ML101) led to the determination of key structural requirements for BIR2 binding affinity. Compounds 9h and 9j sensitized TRAIL-resistant breast cancer cells to apoptotic cell death, highlighting the value of these probe compounds as tools to investigate the biology of XIAP.

Mild one-pot conversion of carboxylic acids to amides or esters with Ph3P/trichloroisocyanuric acid

The reaction of trichloroisocyanuric acid (TCICA) and triphenylphosphine in the presence of a carboxylic acid results in the in situ formation of the corresponding acid chloride under mild conditions. Subsequent addition of amines or alcohols, in the presence of a tertiary amine affords the corresponding amides, or esters, in good to excellent yields. The methodology was applied to the synthesis of a dipeptide.