2-Chloro-6-fluoropyridine-4-boronic acid,pinacol ester

Base Information

• Chemical Name: 2-Chloro-6-fluoropyridine-4-boronic acid,pinacol ester
• CAS No.: 1146615-89-5
• Molecular Formula: C11H14BClFNO2
• Molecular Weight: 257.5
• Hs Code.: 2933399990
• Mol file: 1146615-89-5.mol

Synonyms:2-Chloro-6-fluoropyridine-4-boronic acid,pinacol ester;2-Chloro-6-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Chemical Property of 2-Chloro-6-fluoropyridine-4-boronic acid,pinacol ester

Chemical Property:

• Boiling Point: 344.5±42.0 °C(Predicted)
• PKA: -3.16±0.10(Predicted)
• PSA: 31.35000
• Density: 1.20±0.1 g/cm3(Predicted)
• LogP: 2.17330
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-6-fluoropyridine-4-boronicAcidPinacolEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Chloro-6-fluoropyridine-4-boronic acid, pinacol ester

Technology Process of 2-Chloro-6-fluoropyridine-4-boronic acid,pinacol ester

There total 3 articles about 2-Chloro-6-fluoropyridine-4-boronic acid,pinacol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-chloro-6-fluoropyridine (20885-12-5) + 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane (25015-63-8) → 2-chloro-6-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (1146615-89-5)

Guidance literature:

With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 2,2'-methylenebis( N,N)-dimethylpyridin-4-amine; In tetrahydrofuran; at 20 ℃; regioselective reaction; Glovebox; Inert atmosphere;

DOI:10.1021/acs.orglett.9b02299

Reference yield:

2-chloro-6-fluoropyridine (20885-12-5) + bis(pinacol)diborane (73183-34-3) → 2-chloro-6-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (1146615-89-5) + 6-chloro-2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Guidance literature:

bis(pinacol)diborane; With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4′,5,5′-Tetrahydro-2,2′-bioxazole; In hexane; at 20 ℃; for 0.0833333h; Glovebox; Inert atmosphere;

2-chloro-6-fluoropyridine; In hexane; at 20 ℃; for 4h; Overall yield = 99 percent; Overall yield = 255 mg; regioselective reaction; Glovebox; Inert atmosphere;

DOI:10.1021/acs.orglett.9b02299

Reference yield:

2-chloro-6-fluoropyridine (20885-12-5) + 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane (25015-63-8) → 2-chloro-6-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (1146615-89-5) + 6-chloro-2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Guidance literature:

With bis(2-pyridyl)methane; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; In tetrahydrofuran; at 20 ℃; for 24h; Reagent/catalyst; Overall yield = 91 percent; regioselective reaction; Glovebox; Inert atmosphere;

DOI:10.1021/acs.orglett.9b02299

upstream raw materials:

2-chloro-6-fluoropyridine

bis(pinacol)diborane

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1146615-89-5 2-Chloro-6-fluoropyridine-4-boronic acid,pinacol ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send