1H-Pyrrole-3-carboxylic acid, 5-(2-amino-5-fluoro-4-pyrimidinyl)-2-phenyl-

Base Information

Chemical Name:1H-Pyrrole-3-carboxylic acid, 5-(2-amino-5-fluoro-4-pyrimidinyl)-2-phenyl-
CAS No.:951784-41-1
Molecular Formula:C₁₅H₁₁FN₄O₂
Molecular Weight:298.276
Hs Code.:
Mol file:951784-41-1.mol

Synonyms:1H-Pyrrole-3-carboxylic acid, 5-(2-amino-5-fluoro-4-pyrimidinyl)-2-phenyl-

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Chemical Property of 1H-Pyrrole-3-carboxylic acid, 5-(2-amino-5-fluoro-4-pyrimidinyl)-2-phenyl-

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Technology Process of 1H-Pyrrole-3-carboxylic acid, 5-(2-amino-5-fluoro-4-pyrimidinyl)-2-phenyl-

There total 4 articles about 1H-Pyrrole-3-carboxylic acid, 5-(2-amino-5-fluoro-4-pyrimidinyl)-2-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 5-(2-amino-5-fluoro-pyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester

: 951784-41-1
5-(2-amino-5-fluoro-pyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-carboxylic acid

Guidance literature:: 5-(2-amino-5-fluoro-pyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester; With sodium hydroxide; ethanol; water; for 2h; Heating / reflux;

With hydrogenchloride; In ethanol; water; pH=5;

Reference yield:

: 736991-75-6
2-chloro-4-(1-ethoxy-vinyl)-5-fluoro-pyrimidine

: 951784-41-1
5-(2-amino-5-fluoro-pyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonia / ethanol; water / 1.5 h / 100 °C / Heating in Parr apparatus

2.1: N-Bromosuccinimide; water / tetrahydrofuran / 1.5 h / 20 °C

3.1: sodium hydride / tetrahydrofuran / 0.08 h / 0 °C

3.2: 8 h / 50 °C

3.3: 20 h / 20 °C

4.1: sodium hydroxide; ethanol; water / 2 h / Heating / reflux

4.2: pH 5

With sodium hydroxide; N-Bromosuccinimide; ethanol; ammonia; water; sodium hydride; In tetrahydrofuran; ethanol; water;

Reference yield:

: 951784-39-7
1-(2-amino-5-fluoro-4-pyrimidinyl)-2-bromo-ethanone

: 951784-41-1
5-(2-amino-5-fluoro-pyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.08 h / 0 °C

1.2: 8 h / 50 °C

1.3: 20 h / 20 °C

2.1: sodium hydroxide; ethanol; water / 2 h / Heating / reflux

2.2: pH 5

With sodium hydroxide; ethanol; water; sodium hydride; In tetrahydrofuran;