736991-75-6Relevant academic research and scientific papers
Cdc7 kinase inhibitors: 5-heteroaryl-3-carboxamido-2-aryl pyrroles as potential antitumor agents. 1. Lead finding
Menichincheri, Maria,Albanese, Clara,Alli, Cristina,Ballinari, Dario,Bargiotti, Alberto,Caldarelli, Marina,Ciavolella, Antonella,Cirla, Alessandra,Colombo, Maristella,Colotta, Francesco,Croci, Valter,Dalessio, Roberto,Danello, Matteo,Ermoli, Antonella,Fiorentini, Francesco,Forte, Barbara,Galvani, Arturo,Giordano, Patrizia,Isacchi, Antonella,Martina, Katia,Molinari, Antonio,Moll, Jürgen K.,Montagnoli, Alessia,Orsini, Paolo,Orzi, Fabrizio,Pesenti, Enrico,Pillan, Antonio,Roletto, Fulvia,Scolaro, Alessandra,Tatò, Marco,Tibolla, Marcellino,Valsasina, Barbara,Varasi, Mario,Vianello, Paola,Volpi, Daniele,Santocanale, Corrado,Vanotti, Ermes
, p. 7296 - 7315 (2010)
Cdc7 serine/threonine kinase is a key regulator of DNA synthesis in eukaryotic organisms. Cdc7 inhibition through siRNA or prototype small molecules causes p53 independent apoptosis in tumor cells while reversibly arresting cell cycle progression in prima
ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF
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Page/Page column 162-163, (2021/12/31)
The present invention relates to isoxazolidines of formula I and their use as receptor-interacting protein kinase 1 inhibitors, for example in the treatment of diseases and disorders mediated by RIP kinase (1) such as rheumatoid arthritis (RA), psoriasis, inflammatory bowel disease (IBD), Crohn's disease or ulcerative colitis.
DIHYDROPYRIMIDINE DERIVATIVES AND USES THEREOF IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES
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Page/Page column 39; 257, (2020/01/24)
The application describes dihydropyrimidine derivatives which are useful in the treatment or prevention of HBV infection or of HBV-induced diseases, more particularly of HBV chronic infection or of diseases induced by HBV chronic infection, as well as pharmaceutical or medical applications thereof.
PYRIDINE, PYRAZINE, AND TRIAZINE COMPOUNDS AS ALLOSTERIC SHP2 INHIBITORS
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Paragraph 00385, (2019/05/02)
The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.
TBK/IKK INHIBITOR COMPOUNDS AND USES THEREOF
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Paragraph 1028; 1032; 1193; 1194; 1231; 1232, (2017/01/23)
The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as TBK/IKKε inhibitors.
ALKYNYL ALCOHOLS AND METHODS OF USE
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Page/Page column 94; 95; 230, (2015/03/13)
The invention relates to compounds of Formula (0): wherein A1-A8, R4 and R5 each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.
ALKYNYL ALCOHOLS AND METHODS OF USE
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Paragraph 0336; 0337; 1035; 1036, (2015/03/04)
The invention relates to compounds of Formula (0): wherein A1-A8, R4 and R5 each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.
Facile and regioselective synthesis of novel 2,4-disubstituted-5- fluoropyrimidines as potential kinase inhibitors
Wada, Hiroki,Cheng, Lili,Jiang, Ji,Jiang, Zhigan,Xie, Jun,Hu, Tao,Sanganee, Hitesh,Luker, Tim
scheme or table, p. 1720 - 1724 (2012/05/04)
2,4-Disubstituted-5-fluoropyrimidine is a biologically active molecular core seen in various anticancer agents such as 5-fluorouracil (5-FU). As part of a programme aimed at discovering kinase inhibitors, routes to two series of novel compounds (5-fluorop
PYRIDYL- AND PYRIMIDINYL-SUBSTITUTED PYRROLE-, THIOPHENE- AND FURANE-DERIVATIVES AS KINASE INHIBITORS
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Page/Page column 58, (2008/06/13)
The present invention provides compounds of the formula (I), or the pharmaceutically acceptable salts thereof, wherein G, W, R2, R3, R4, R5 and R6 are as defined in the specification. Further objects
