Ethyl quinuclidine-4-carboxylate hydrochloride

Base Information

• Chemical Name: Ethyl quinuclidine-4-carboxylate hydrochloride
• CAS No.: 22766-67-2
• Molecular Formula: C10H18ClNO2
• Molecular Weight: 219.711
• Mol file: 22766-67-2.mol

Synonyms:Ethyl quinuclidine-4-carboxylate hydrochloride;ETHYL QUINUCLIDINE-4-CARBOXYLATE HCL

Chemical Property of Ethyl quinuclidine-4-carboxylate hydrochloride

Chemical Property:

• Melting Point: 298-299 °C
• PSA: 29.54000
• LogP: 1.77530
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

Ethyl4-QuinuclidinecarboxylateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ethyl 4-Quinuclidinecarboxylate Hydrochloride is a useful reagent for organic synthesis applied in the synthesis of other aminoquinuclidine derivatives.

Technology Process of Ethyl quinuclidine-4-carboxylate hydrochloride

There total 2 articles about Ethyl quinuclidine-4-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

azabicyclo[2.2.2]octane-4-carboxylic acid ethyl ester (22766-68-3) → 1-azabicyclo[2.2.2]octane-4-carboxylic acid ethyl ester hydrochloride (22766-67-2)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; at 0 - 20 ℃; for 4h; Solvent; Temperature;

Reference yield:

→ 1-azabicyclo[2.2.2]octane-4-carboxylic acid ethyl ester hydrochloride (22766-67-2)

Guidance literature:

1a1, HCl/Ae.;

DOI:10.1002/hlca.19720550719

Reference yield: 97.8%

1-azabicyclo[2.2.2]octane-4-carboxylic acid ethyl ester hydrochloride (22766-67-2) + phenylmagnesium bromide (100-58-3) → (1-azabicyclo[2.2.2]octane-4-yl)(diphenyl)methanol hydrochloride

Guidance literature:

1-azabicyclo[2.2.2]octane-4-carboxylic acid ethyl ester hydrochloride; phenylmagnesium bromide; In 2-methyltetrahydrofuran; at 50 - 60 ℃; for 2h; Inert atmosphere;

With hydrogenchloride; In 2-methyltetrahydrofuran; water; at 0 - 5 ℃;

upstream raw materials:

azabicyclo[2.2.2]octane-4-carboxylic acid ethyl ester

Downstream raw materials:

Umeclidinium bromide

α,α-diphenyl-1-azabicyclo[2.2.2]octane-4-methanol

azabicyclo[2.2.2]octane-4-carboxylic acid ethyl ester

Refernces