ETHYL 2,3,5,6-TETRAMETHYLBENZOYLFORMATE

Base Information

• Chemical Name: ETHYL 2,3,5,6-TETRAMETHYLBENZOYLFORMATE
• CAS No.: 80120-38-3
• Molecular Formula: C14H18O3
• Molecular Weight: 234.3
• Hs Code.: 2918300090
• Mol file: 80120-38-3.mol

Synonyms:ETHYL 2,3,5,6-TETRAMETHYLBENZOYLFORMATE

Chemical Property of ETHYL 2,3,5,6-TETRAMETHYLBENZOYLFORMATE

Chemical Property:

• Vapor Pressure: 2.46E-05mmHg at 25°C
• Boiling Point: 358.9°C at 760 mmHg
• Flash Point: 162.9°C
• PSA: 43.37000
• Density: 1.052g/cm³
• LogP: 2.66600

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2,3,5,6-tetramethylbenzoylformate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ETHYL 2,3,5,6-TETRAMETHYLBENZOYLFORMATE

There total 3 articles about ETHYL 2,3,5,6-TETRAMETHYLBENZOYLFORMATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-chloro-2,3,5,6-tetramethylbenzene (2762-20-1) + Ethyl oxalyl chloride (4755-77-5) → ethyl (2,3,5,6-tetramethylphenyl)-2-oxoacetate (80120-38-3)

Guidance literature:

1-chloro-2,3,5,6-tetramethylbenzene; With naphthalene; lithium; In diethyl ether; at 3 - 6 ℃; for 3h;

With copper(l) cyanide; In tetrahydrofuran; diethyl ether; at 3 - 6 ℃; for 0.5h;

Ethyl oxalyl chloride; In tetrahydrofuran; diethyl ether; at 3 - 20 ℃; for 1.33333h; Cooling with ice;

DOI:10.1021/ol302672n

Reference yield: 57.0%

1,4-dichlorodurene (1967-89-1) + Ethyl oxalyl chloride (4755-77-5) → ethyl (2,3,5,6-tetramethylphenyl)-2-oxoacetate (80120-38-3) + C18H22O6

Guidance literature:

1,4-dichlorodurene; With naphthalene; lithium; In diethyl ether; at 20 ℃; for 19h;

Ethyl oxalyl chloride; In diethyl ether; at 20 ℃; Cooling with liquid nitrogen;

DOI:10.1021/ol302672n

Reference yield:

1,4-dichlorodurene (1967-89-1) + Ethyl oxalyl chloride (4755-77-5) → ethyl (2,3,5,6-tetramethylphenyl)-2-oxoacetate (80120-38-3) + ethyl (4-chloro-2,3,5,6-tetramethylphenyl)-2-oxoacetate + C18H22O6

Guidance literature:

1,4-dichlorodurene; With lithium; In diethyl ether; at 20 ℃; for 24h;

Ethyl oxalyl chloride; In diethyl ether; Overall yield = 1.51 g;

DOI:10.1021/ol302672n

upstream raw materials:

1-chloro-2,3,5,6-tetramethylbenzene

Ethyl oxalyl chloride

1,4-dichlorodurene

Refernces