5-Amino-2-bromo-4,6-dimethylpyridine

Base Information

• Chemical Name: 5-Amino-2-bromo-4,6-dimethylpyridine
• CAS No.: 897733-12-9
• Molecular Formula: C₇H₉BrN₂
• Molecular Weight: 201.066
• Hs Code.: 2933399090
• Mol file: 897733-12-9.mol

Synonyms:6-Bromo-2,4-dimethylpyridin-3-amine, 3-Amino-6-bromo-2,4-lutidine;6-bromo-2,4-dimethyl-3-aminopyridine;6-bromo-2,4-dimethyl-3-Pyridinamine

Chemical Property of 5-Amino-2-bromo-4,6-dimethylpyridine

Chemical Property:

• PSA: 38.91000
• LogP: 2.62430
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

6-Bromo-2,4-dimethylpyridin-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Amino-2-bromo-4,6-dimethylpyridine

There total 1 articles about 5-Amino-2-bromo-4,6-dimethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.3%

3-amino-2,4-dimethylpyridine (1073-21-8) → 6-bromo-2,4-dimethyl-pyridin-3-amine (897733-12-9)

Guidance literature:

With bromine; In dichloromethane; at 0 - 20 ℃; for 12.0833h;

Reference yield:

6-bromo-2,4-dimethyl-pyridin-3-amine (897733-12-9) → methyl 5-[[6-[3-[[tert-butyl(dimethyl)silyl]oxymethyl]phenyl]-3-methyl-pyridine-2-carbonyl]amino]-4,6-dimethyl-pyridine-2-carboxylate

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate / acetonitrile / 3 h / 85 °C / 5171.77 Torr / Autoclave

2.1: isobutyl chloroformate; 4-methyl-morpholine / tetrahydrofuran / 0.33 h / 0 °C

2.2: 12 h / 20 °C

With 4-methyl-morpholine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; triethylamine; isobutyl chloroformate; In tetrahydrofuran; acetonitrile;

upstream raw materials:

3-amino-2,4-dimethylpyridine