1073-21-8

Usage

Uses

Used in Pharmaceutical Synthesis:
3-Amino-2,4-dimethylpyridine is used as a key intermediate in the synthesis of diazepines and their derivatives, which are known for their diverse range of biological activities, including sedative, hypnotic, and anxiolytic effects. The compound plays a crucial role in the development of new drugs targeting the central nervous system.
Used in Chemical Research:
In addition to its pharmaceutical applications, 3-Amino-2,4-dimethylpyridine is also utilized as a reagent in various chemical research studies. Its unique structure allows for the exploration of novel chemical reactions and the synthesis of new compounds with potential applications in various fields, such as materials science, agrochemistry, and environmental science.

InChI:InChI=1/C7H10N2/c1-5-3-4-9-6(2)7(5)8/h3-4H,8H2,1-2H3

Upstream product

• 1074-76-6 2,4-dimethyl-3-nitropyridine 
• 55314-30-2 2,4-dimethylnicotinic acid 
• 108-47-4 2,4-lutidine 
• 22934-24-3 3-nitro-6-hydroxy-2,4-dimethylpyridine 
• 89793-08-8 6-chloro-2,4-dimethyl-3-nitropyridine 

Downstream Products

• 27296-76-0 2,4-dimethyl-pyridin-3-ol 
• 860411-35-4 7-methyl-3H-pyrazolo[3,4-c]pyridine 
• 1417332-55-8 1-(4-Methoxy-phenyl)-3-methyl-6-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid (2,4-dimethyl-pyridin-3-yl)-amide 
• 1421251-56-0 2-(2,6-diethylphenyl)-6-(2,4-dimethylpyridin-3-yl)-4-methyl-5,6,7,8-tetrahydro(5,5-²H₂)-1,6-naphthyridine 
• 1421254-08-1 2-(2,6-diethylphenyl)-6-(2,4-dimethylpyridin-3-yl)-4-methyl-7,8-dihydro-1,6-naphthyridin-5(6H)-one 
• 1421254-07-0 2-(2,6-diethylphenyl)-6-(2,4-dimethylpyridin-3-yl)-4-methyl-1,6-naphthyridin-5(6H)-one 
• 1417331-93-1 1-(4-Methoxy-phenyl)-3,6-dimethyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid (2,4-dimethyl-pyridin-3-yl)-amide 
• 1345828-49-0 1-(4-fluoro-phenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid (2,4-dimethyl-pyridin-3-yl)-amide 
• 897733-12-9 6-bromo-2,4-dimethyl-pyridin-3-amine 
• 143509-33-5 2,4-dimethyl-3-hydroxypyridine N-oxide 

Relevant academic research and scientific papers

Synthesis and Antitumor Activity of 3- and 5-Hydroxy-4-methylpyridibe-2-carboxaldehyde Thiosemicarbazones

To develop an α-(N)-heterocyclic carboxaldehyde thiosemicarbazone with clinical utility as an anticancer agent, two analogues, 3-hydroxy-4-methylpyridine-2-carboxaldehyde thiosemicarbazone (3-HMP) and 5-hydroxy-4-methylpyridine-2-carboxaldehyde thiosemicarbazone (5-HMP), of 5-hydroxypyridine-2-carboxaldehyde thiosemicarbazone (5-HP) have been designed and synthesized by two different methods. 3-HMP and 5-HMP both showed better antitumor activity than their respective parent compounds, 3-hydroxypyridine-2-carboxaldehyde thiosemicarbazone and 5-HP, in mice bearing the L1210 leukemia.

DERIVATIVES OF 4-(N-AZACYCLOALKYL) ANILIDES AS POTASSIUM CHANNEL MODULATORS

This invention provides potassium channel modulators which are compounds of formula I where at least one of W and Z is N; where the moiety is one of Groups A or B below A where Ar is a 1,2-fused, six membered ring aromatic group, bearing substituents R1 and R2 as defined below, and containing zero or one ring nitrogen atom; and where other substituents are defined herein. The invention also provides a composition comprising a pharmaceutically acceptable carrier and at least one of the following: i) a pharmaceutically effective amount of a compound of formula I and ii) a pharmaceutically acceptable salt, ester, or prodrug thereof. The invention also provides a method of preventing or treating a disease or disorder which is affected by activities of potassium channels, comprising administering to a patient in need thereof a therapeutically effective amount of a compound of formula I or a salt, ester, or prodrug thereof.

Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto

The present invention relates to certain substituted pyridinyl and pyrimidinyl derivatives of Fomula (Ia) that are modulators of metabolism. Accordingly, compounds of the present invention are useful in the treatment of metabolic-related disorders and com

2-formylpyridine thiosemicarbazone compounds

A method of treatment of tumors is provided based upon a compound of the formula STR1 Some aspects of the invention were supported in part by U.S. Public Health Service Grant CA-02817 from the National Cancer Institute and support from the Northeast NMR Facility at Yale University insofar as the use of high resolution NMR spectra is concerned that was made possible by a grant from the Chemical Division of the National Science Foundation (Grant No. CHE-7916210).

Studies on Diazepines. XXVIII. Syntheses of 5H-1,3-Diazepines and 2H-1,4-Diazepines from 3-Azidopyridines

Photolysis of 2-unsubstituted (5a-f) and 2,4-disubstituted (5k, l) 3-azidopyridines in the presence of sodium methoxide resulted in ring expansion to give the 4-methoxy-5H-1,3-diazepines (8 and 18), presumably via the azirine intermediates 6 and 17 derived from the initially formed singlet 3-pyridylnitrenes by cyclization at the 2-position of the pyridine ring.On the other hand, in the photolysis of 2-substituted 3-azidopyridines (5g-j), the cyclization of the nitrenes occurred predominantly at the vacant 4-position giving rise to the 3-methoxy-2H-1,4-diazepines (13).Keywords--3-azidopyridine; photolysis; pyridylnitrene; ring expansion; 5H-1,3-diazepine; 2H-1,4-diazepine; azirine intermediate