5-Chloro-4-iodopyridin-2-amine

Base Information

• Chemical Name: 5-Chloro-4-iodopyridin-2-amine
• CAS No.: 1260667-65-9
• Molecular Formula: C5H4ClIN2
• Molecular Weight: 254.458
• Hs Code.: 2933399990
• European Community (EC) Number: 821-243-6
• Mol file: 1260667-65-9.mol

Synonyms:5-CHLORO-4-IODOPYRIDIN-2-AMINE;1260667-65-9;2-Amino-5-chloro-4-iodopyridine;MFCD18250085;5-Chloro-4-iodo-pyridin-2-amine;SCHEMBL1439801;PMLVDYBLXQYWLI-UHFFFAOYSA-N;2-Pyridinamine, 5-chloro-4-iodo-;AKOS025213429;AB72299;BS-50158;SY270510;CS-0143877;EN300-226237

Chemical Property of 5-Chloro-4-iodopyridin-2-amine

Chemical Property:

• PSA: 38.91000
• LogP: 2.50300
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 253.91077
• Heavy Atom Count: 9
• Complexity: 101

Purity/Quality:

99% ^*data from raw suppliers

5-Chloro-4-iodopyridin-2-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=C(C(=CN=C1N)Cl)I

Technology Process of 5-Chloro-4-iodopyridin-2-amine

There total 1 articles about 5-Chloro-4-iodopyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-chloro-2-fluoro-4-iodopyridine (659731-48-3) → 5-chloro-4-iodo-pyridin-2-amine (1260667-65-9)

Guidance literature:

With ammonium hydroxide; In 1-methyl-pyrrolidin-2-one; water; at 100 ℃; for 17h; Temperature; Microwave irradiation;

Reference yield: 64.4%

(1S,3R)-3-((tert-butoxycarbonyl)amino)cyclo hexane-1-carboxylic acid (222530-34-9,218772-92-0,222530-33-8) + 5-chloro-4-iodo-pyridin-2-amine (1260667-65-9) → tert-butyl ((1R,3S)-3-((5-chloro-4-iodopyridin-2-yl)carbamoyl)cyclohexyl)carbamate

Guidance literature:

(1S,3R)-3-((tert-butoxycarbonyl)amino)cyclo hexane-1-carboxylic acid; With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; In dichloromethane; at 17 - 25 ℃; for 1h; Inert atmosphere; Cooling with ice;

5-chloro-4-iodo-pyridin-2-amine; With pyridine; In dichloromethane; at 17 - 25 ℃; for 16h; Inert atmosphere;

Reference yield: 37.0%

racemic trans-3-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylic acid (218772-92-0,222530-33-8) + 5-chloro-4-iodo-pyridin-2-amine (1260667-65-9) → tert-butyl (trans-3-((5-chloro-4-iodopyridin-2-yl)carbamoyl)cyclohexyl)carbamate

Guidance literature:

racemic trans-3-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylic acid; With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; In dichloromethane; at 0 - 20 ℃; for 1.5h; Inert atmosphere;

5-chloro-4-iodo-pyridin-2-amine; With pyridine; In dichloromethane; for 70h; Inert atmosphere;

upstream raw materials:

5-chloro-2-fluoro-4-iodopyridine

Downstream raw materials:

(R)-tert-butyl 3-(5-chloro-4-phenylpyridin-2-ylcarbamoyl)piperidine-1-carboxylate trifluoroacetate

(R)-3-[5'-chloro-6-(cyclohexylmethylamino)-[2,4,]bipyridinyl-2'-ylcarbamoyl]piperidine-1-carboxylic acid tert-butyl ester

5-chloro-3-(2-methoxyphenyl)pyridin-2-amine

(1S,3R)-3-acetamido-N-(5-chloro-4-(5,5-dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)pyridin-2-yl)cyclohexane-1-carboxamide

Refernces

• 1、 Barlaam, Bernard,Casella, Robert,Cidado, Justin,Cook, Calum,De Savi, Chris,Dishington, Allan,Donald, Craig S.,Drew, Lisa,Ferguson, Andrew D.,Ferguson, Douglas,Glossop, Steve,Grebe, Tyler,Gu, Chungang,Hande, Sudhir,Hawkins, Janet,Hird, Alexander W.,Holmes, Jane,Horstick, James,Jiang, Yun,Lamb, Michelle L.,McGuire, Thomas M.,Moore, Jane E.,O'Connell, Nichole,Pike, Andy,Pike, Kurt G.,Proia, Theresa,Roberts, Bryan,San Martin, Maryann,Sarkar, Ujjal,Shao, Wenlin,Stead, Darren,Sumner, Neil,Thakur, Kumar,Vasbinder, Melissa M.,Varnes, Jeffrey G.,Wang, Jianyan,Wang, Lei,Wu, Dedong,Wu, Liangwei,Yang, Bin,Yao, Tieguang. "Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies". . p. 15564 - 15590. Retrieved 2021/01/09.
• 2、 -. "Chemical Compounds". Paragraph 0568. . Retrieved 2017/01/19.