(R)-tert-butyl 3-(5-chloro-4-phenylpyridin-2-ylcarbamoyl)piperidine-1-carboxylate trifluoroacetate

Base Information

Chemical Name:(R)-tert-butyl 3-(5-chloro-4-phenylpyridin-2-ylcarbamoyl)piperidine-1-carboxylate trifluoroacetate
CAS No.:1269815-52-2
Molecular Formula:C₂HF₃O₂*C₂₂H₂₆ClN₃O₃
Molecular Weight:529.944
Hs Code.:

Synonyms:(R)-tert-butyl 3-(5-chloro-4-phenylpyridin-2-ylcarbamoyl)piperidine-1-carboxylate trifluoroacetate

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Chemical Property of (R)-tert-butyl 3-(5-chloro-4-phenylpyridin-2-ylcarbamoyl)piperidine-1-carboxylate trifluoroacetate

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Technology Process of (R)-tert-butyl 3-(5-chloro-4-phenylpyridin-2-ylcarbamoyl)piperidine-1-carboxylate trifluoroacetate

There total 4 articles about (R)-tert-butyl 3-(5-chloro-4-phenylpyridin-2-ylcarbamoyl)piperidine-1-carboxylate trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 659731-48-3
5-chloro-2-fluoro-4-iodopyridine

: 1269815-52-2
(R)-tert-butyl 3-(5-chloro-4-phenylpyridin-2-ylcarbamoyl)piperidine-1-carboxylate trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonia / water; dimethyl sulfoxide / 18 h / 90 °C

2.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 - 20 °C

2.2: 2 h / 20 °C

3.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 1.5 h / 95 °C

With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; ammonia; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide; 3.1: Suzuki Coupling;

Reference yield:

: 1269754-97-3
(R)-tert-butyl 3-(5-chloro-4-iodopyridin-2-ylcarbamoyl)piperidine-1-carboxylate

: 76-05-1
trifluoroacetic acid

: 98-80-6
phenylboronic acid

: 1269815-52-2
(R)-tert-butyl 3-(5-chloro-4-phenylpyridin-2-ylcarbamoyl)piperidine-1-carboxylate trifluoroacetate

Guidance literature:: (R)-tert-butyl 3-(5-chloro-4-iodopyridin-2-ylcarbamoyl)piperidine-1-carboxylate; phenylboronic acid; With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; water; at 95 ℃; for 1.5h;

trifluoroacetic acid;

Reference yield:

: 1260667-65-9
5-chloro-4-iodo-pyridin-2-amine

: 1269815-52-2
(R)-tert-butyl 3-(5-chloro-4-phenylpyridin-2-ylcarbamoyl)piperidine-1-carboxylate trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 - 20 °C

1.2: 2 h / 20 °C

2.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 1.5 h / 95 °C

With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; dichloromethane; water; 2.1: Suzuki Coupling;