2-[5-(HYDROXYMETHYL)-2-PYRIDINYL]-BENZONITRILE

Base Information

Chemical Name:2-[5-(HYDROXYMETHYL)-2-PYRIDINYL]-BENZONITRILE
CAS No.:145733-56-8
Molecular Formula:C13H10N2O
Molecular Weight:210.235
Hs Code.:2933399090

Synonyms:2-[5-(HYDROXYMETHYL)-2-PYRIDINYL]-BENZONITRILE;2-(5-(HydroxyMethyl)pyridin-2-yl)benzonitrile

Suppliers and Price of 2-[5-(HYDROXYMETHYL)-2-PYRIDINYL]-BENZONITRILE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[5-(HYDROXYMETHYL)-2-PYRIDINYL]-BENZONITRILE

Chemical Property:

PSA：56.91000
LogP:2.11258

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-[5-(HYDROXYMETHYL)-2-PYRIDINYL]-BENZONITRILE

There total 5 articles about 2-[5-(HYDROXYMETHYL)-2-PYRIDINYL]-BENZONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 145733-55-7
2-<5-<<(tert-butyldimethylsilyl)oxy>methyl>pyridin-2-yl>benzonitrile

: 145733-56-8
2-<5-(hydroxymethyl)pyridin-2-yl>benzonitrile

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 5h;
DOI:10.1039/c8cc08930b

Reference yield:

: nBu₄ NF hydrate

: 145733-55-7
2-<5-<<(tert-butyldimethylsilyl)oxy>methyl>pyridin-2-yl>benzonitrile

: 145733-56-8
2-<5-(hydroxymethyl)pyridin-2-yl>benzonitrile

Guidance literature:: In tetrahydrofuran;

Reference yield:

: 6311-35-9
6-bromonicotinic acid

: 145733-56-8
2-<5-(hydroxymethyl)pyridin-2-yl>benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 59 percent / BH₃ / tetrahydrofuran / 3 h / Ambient temperature

2: 97 percent / dimethylformamide / 1 h

3: 1.) n-BuLi, 2.) tri-n-butyltin chloride, 3.) CuI, bis(triphenylphosphine)palladium(II) chloride

4: 80 percent / n-Bu₄NF hydrate / tetrahydrofuran / 18 h / Ambient temperature

With copper(l) iodide; n-butyllithium; bis(triphenylphosphine)palladium(II)-chloride; borane; tributyltin chloride; tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00030a013