4-Methyl-3-(hydroxyMethyl)Morpholine

Base Information

• Chemical Name: 4-Methyl-3-(hydroxyMethyl)Morpholine
• CAS No.: 1159598-86-3
• Molecular Formula: C6H13NO2
• Molecular Weight: 131.175
• Hs Code.: 2934999090
• Mol file: 1159598-86-3.mol

Synonyms:4-Methyl-3-(hydroxyMethyl)Morpholine;(4-Methylmorpholin-3-yl)methanol;4-Methyl-3-morpholinemethanol

Chemical Property of 4-Methyl-3-(hydroxyMethyl)Morpholine

Chemical Property:

• Boiling Point: 201.1±15.0 °C(Predicted)
• PKA: 14.85±0.10(Predicted)
• PSA: 32.70000
• Density: 1.031±0.06 g/cm3(Predicted)
• LogP: -0.75280
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

4-Methyl-3-(hydroxymethyl)morpholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Methyl-3-(hydroxyMethyl)Morpholine

There total 2 articles about 4-Methyl-3-(hydroxyMethyl)Morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

tert-Butyl 3-(hydroxymethyl)-4-morpholinecarboxylate (473923-56-7) → 4-methyl-3-(hydroxymethyl)morpholine (1159598-86-3,1620510-51-1,1620510-50-0)

Guidance literature:

tert-Butyl 3-(hydroxymethyl)-4-morpholinecarboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; at -10 - 20 ℃; Heating / reflux;

With water; In tetrahydrofuran;

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + (rac)-3-hydroxymethylmorpholine (106910-83-2) → 4-methyl-3-(hydroxymethyl)morpholine (1159598-86-3,1620510-51-1,1620510-50-0)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; water; at 20 ℃;

Reference yield: 83.0%

4-methyl-3-(hydroxymethyl)morpholine (1159598-86-3,1620510-51-1,1620510-50-0) + 4-(4-fluorophenyl)-piperazine-1-carboxylic acid 4-nitrophenyl ester (1159598-28-3) → (4-methylmorpholin-3-yl)methyl 4-(4-fluorophenyl)piperazine-1-carboxylate (1159598-85-2)

Guidance literature:

4-methyl-3-(hydroxymethyl)morpholine; With sodium hydride; In tetrahydrofuran; at 0 ℃;

4-(4-fluorophenyl)-piperazine-1-carboxylic acid 4-nitrophenyl ester; In tetrahydrofuran; at 20 ℃;

upstream raw materials:

tert-Butyl 3-(hydroxymethyl)-4-morpholinecarboxylate

formaldehyd

(rac)-3-hydroxymethylmorpholine

Downstream raw materials:

(4-methylmorpholin-3-yl)methyl 4-(4-fluorophenyl)piperazine-1-carboxylate

(4-methylmorpholin-3-yl)methyl 4-(2,4-difluorophenyl)piperazine-1-carboxylate