1-(Methylsulfonyl)-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine

Base Information

• Chemical Name: 1-(Methylsulfonyl)-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine
• CAS No.: 1428329-80-9
• Molecular Weight: 365.3
• Mol file: 1428329-80-9.mol

Synonyms:1-(Methylsulfonyl)-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine;Piperidine,1-(methylsulfonyl)-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-

Chemical Property of 1-(Methylsulfonyl)-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine

Chemical Property:

• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-(Methylsulfonyl)-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(Methylsulfonyl)-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine

There total 2 articles about 1-(Methylsulfonyl)-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-bromophenyl)-1-(methylsulfonyl)piperidine (622386-94-1) + bis(pinacol)diborane (73183-34-3) → 1-(methylsulfonyl)-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine (1428329-80-9)

Guidance literature:

4-(4-bromophenyl)-1-(methylsulfonyl)piperidine; bis(pinacol)diborane; With potassium acetate; In dimethyl sulfoxide; for 0.25h; Inert atmosphere;

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dimethyl sulfoxide; at 80 ℃;

Reference yield:

4-(4’-bromophenyl)piperidine (80980-89-8) → 1-(methylsulfonyl)-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine (1428329-80-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dmap; triethylamine / dichloromethane / 1 h / 20 - 24 °C

2.1: potassium acetate / dimethyl sulfoxide / 0.25 h / Inert atmosphere

2.2: 80 °C

With dmap; potassium acetate; triethylamine; In dichloromethane; dimethyl sulfoxide;

Reference yield:

(5aR,6S,6aS)-ethyl 3-((5-bromo-2-fluoro-4-(trifluoromethyl)benzyl)oxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate + 1-(methylsulfonyl)-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine (1428329-80-9) → (5aR,6S,6aS)-3-((4-fluoro-4’-(1-(methylsulfonyl)piperidin-4-yl)-6-(trifluoromethyl)-[1,1‘-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid

Guidance literature:

Multi-step reaction with 2 steps

1: chloro(2-dicyclohexylphosphino-2‘,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl)]palladium(II); potassium phosphate / tetrahydrofuran; water / 5 h / 65 °C / Inert atmosphere

2: lithium hydroxide; water / tetrahydrofuran; ethanol / 15 h / 20 - 24 °C

With potassium phosphate; chloro(2-dicyclohexylphosphino-2‘,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl)]palladium(II); water; lithium hydroxide; In tetrahydrofuran; ethanol; water;

upstream raw materials:

4-(4’-bromophenyl)piperidine

4-(4-bromophenyl)-1-(methylsulfonyl)piperidine

bis(pinacol)diborane