1H-Pyrrolo[2,3-c]pyridine-3-acetic acid, 4-Methoxy-7-(3-Methyl-1H-1,2,4-triazol-1-yl)-α-oxo-

Base Information

Chemical Name:1H-Pyrrolo[2,3-c]pyridine-3-acetic acid, 4-Methoxy-7-(3-Methyl-1H-1,2,4-triazol-1-yl)-α-oxo-
CAS No.:676491-47-7
Molecular Formula:C13H11N5O4
Molecular Weight:301.261
Hs Code.:
Mol file:676491-47-7.mol

Synonyms:1H-Pyrrolo[2,3-c]pyridine-3-acetic acid, 4-Methoxy-7-(3-Methyl-1H-1,2,4-triazol-1-yl)-α-oxo-;1H-Pyrrolo[2,3-c]pyridine-3-acetic acid, 4-Methoxy-7-(3-Methyl-1H-1,2,4-triazol-1-yl)-α-oxo-12;2-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetic acid

Suppliers and Price of 1H-Pyrrolo[2,3-c]pyridine-3-acetic acid, 4-Methoxy-7-(3-Methyl-1H-1,2,4-triazol-1-yl)-α-oxo-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
1H-Pyrrolo[2,3-c]pyridine-3-aceticacid,4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-α-oxo- 95.77%
100mg
$ 1300.00

Chemenu
2-(4-Methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoaceticacid 95%+
100mg
$ 2275.00

Total 10 raw suppliers

Chemical Property of 1H-Pyrrolo[2,3-c]pyridine-3-acetic acid, 4-Methoxy-7-(3-Methyl-1H-1,2,4-triazol-1-yl)-α-oxo-

Chemical Property:

Boiling Point:645.5±65.0 °C(Predicted)
PKA:2.59±0.54(Predicted)
PSA：122.99000
Density:1 +-.0.1 g/cm3(Predicted)
LogP:0.72790

Purity/Quality:

99%, ^*data from raw suppliers

1H-Pyrrolo[2,3-c]pyridine-3-aceticacid,4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-α-oxo- 95.77% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrolo[2,3-c]pyridine-3-acetic acid, 4-Methoxy-7-(3-Methyl-1H-1,2,4-triazol-1-yl)-α-oxo-

There total 2 articles about 1H-Pyrrolo[2,3-c]pyridine-3-acetic acid, 4-Methoxy-7-(3-Methyl-1H-1,2,4-triazol-1-yl)-α-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98198-48-2
2-amino-5-bromo-4-methylpyridine

: 676491-47-7
2-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: sulfuric acid; nitric acid / water / 7 h / 25 - 33 °C / Large scale

2.1: tert.-butylnitrite; sulfuric acid / 9.5 h / 20 - 43 °C / Large scale

3.1: N,N-dimethyl-formamide / 80 - 100 °C / Large scale

4.1: methanol; propanoic acid methyl ester; copper(l) iodide / tetrahydrofuran / 21 h / 30 - 72 °C / Large scale

5.1: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 24 h / 25 - 35 °C / 1275.13 - 1500.15 Torr / Autoclave; Large scale

5.2: 10 - 30 °C / Large scale

6.1: trichlorophosphate / neat (no solvent) / 15 h / 40 - 102 °C / Large scale

7.1: methanol / toluene / 8 h / 45 - 55 °C / Large scale

8.1: Methyl isobutyl carbinol / 76 h / 130 - 145 °C / Large scale

9.1: isopropylmagnesium chloride; pyridine / 2-methyltetrahydrofuran / -25 - -10 °C / Large scale

9.2: 3 h / -25 - -10 °C / Large scale

10.1: potassium tert-butylate; water / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 1 h / 15 - 40 °C / Large scale

With pyridine; methanol; Methyl isobutyl carbinol; copper(l) iodide; tert.-butylnitrite; propanoic acid methyl ester; sulfuric acid; 5%-palladium/activated carbon; potassium tert-butylate; water; hydrogen; isopropylmagnesium chloride; nitric acid; trichlorophosphate; In tetrahydrofuran; 2-methyltetrahydrofuran; 1-methyl-pyrrolidin-2-one; water; ethyl acetate; N,N-dimethyl-formamide; toluene; 2.1: |Sandmeyer Reaction / 3.1: |Leimgruber-Batcho Indole Synthesis / 5.1: |Leimgruber-Batcho Indole Synthesis;
DOI:10.1021/acs.oprd.7b00134

Reference yield:

: 67443-38-3
5-bromo-2-chloro-3-nitropyridine

: 676491-47-7
2-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 1.5 h / -78 °C / Inert atmosphere

2: copper(l) iodide / methanol / 110 °C / Microwave irradiation; Inert atmosphere

3: 20 h / 143 °C / Inert atmosphere

4: aluminum (III) chloride / dichloromethane / 20 °C

5: sodium hydroxide / methanol; water / 0.25 h / 20 °C

With aluminum (III) chloride; copper(l) iodide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/j.bmcl.2014.10.027

Reference yield: 76.0%

: 676491-47-7
2-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetic acid

: 5-phenyl-1,2,3,4-tetrahydro-2,6-naphthyridine trifluoroacetate

: 1-(4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-(5-phenyl-3,4-dihydro-2,6-naphthyridin-2(1H)-yl)ethane-1,2-dione trifluoroacetate

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 5h;