10-(β-Hydroxypropyl)phenothiazine

Base Information

• Chemical Name: 10-(β-Hydroxypropyl)phenothiazine
• CAS No.: 32209-47-5
• Molecular Formula: C₁₅H₁₅NOS
• Molecular Weight: 257.356
• Mol file: 32209-47-5.mol

Synonyms:10-(β-Hydroxypropyl)phenothiazine;α-Methyl-10H-phenothiazine-10-ethanol;α-Methyl-phenothiazine-10-ethanol

Chemical Property of 10-(β-Hydroxypropyl)phenothiazine

Chemical Property:

• Melting Point: 78 °C
• Boiling Point: 185-190 °C(Press: 0.3 Torr)
• PKA: 14.52±0.20(Predicted)
• PSA: 48.77000
• Density: 1.233±0.06 g/cm3(Predicted)
• LogP: 3.73510
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

α-Methyl-phenothiazine-10-ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 10-(β-Hydroxypropyl)phenothiazine

There total 2 articles about 10-(β-Hydroxypropyl)phenothiazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

10H-phenothiazine (92-84-2) + methyloxirane (75-56-9,16033-71-9) → 1-(10H-phenothiazin-10-yl)propan-2-ol (32209-47-5)

Guidance literature:

With methyllithium; 1.) ether, r.t., 30 min, 2.) r.t., 1 h;

DOI:10.1002/ardp.19813140812

Reference yield:

10H-phenothiazine (92-84-2) → 1-(10H-phenothiazin-10-yl)propan-2-ol (32209-47-5)

Guidance literature:

With methyloxirane; In 5,5-dimethyl-1,3-cyclohexadiene; water;

Reference yield:

1-(10H-phenothiazin-10-yl)propan-2-ol (32209-47-5) → C24H23NO3S

Guidance literature:

Multi-step reaction with 2 steps

1: Lipozyme TL IM / hexane / 24 h / 25 °C / Resolution of racemate; Enzymatic reaction

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 24 h / 20 °C

With dmap; Lipozyme TL IM; dicyclohexyl-carbodiimide; In hexane; dichloromethane;

DOI:10.3762/bjoc.10.322

upstream raw materials:

10H-phenothiazine

methyloxirane

Downstream raw materials:

phosphorous acid bis-(1-methyl-2-phenothiazin-10-yl-ethyl) ester phenyl ester

phosphoric acid 2-chloro-phenyl ester ethyl ester 1-methyl-2-phenothiazin-10-yl-ethyl ester

Refernces

• 1、 -. "Substituted or unsubstituted benzhydryl heteroalkyl-substituted aminophenol compounds and pharmaceutical compositions thereof". . . Retrieved 2008/06/13.