Cyclohexanepropiolamide (8CI)

Base Information

• Chemical Name: Cyclohexanepropiolamide (8CI)
• CAS No.: 4361-26-6
• Molecular Formula: C₉H₁₃NO
• Molecular Weight: 151.208
• Mol file: 4361-26-6.mol

Synonyms:Cyclohexanepropiolamide (8CI)

Chemical Property of Cyclohexanepropiolamide (8CI)

Chemical Property:

• PSA: 43.09000
• LogP: 1.75570

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclohexanepropiolamide (8CI)

There total 3 articles about Cyclohexanepropiolamide (8CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

cyclohexylpropynoic acid methyl ester (42134-60-1) → cyclohexyl-propiolic acid amide (4361-26-6)

Guidance literature:

With ammonia; In tetrahydrofuran; ethanol; at 0 ℃; for 2h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.0c02567

Reference yield:

2-cyclohexylacetylene (931-48-6) → cyclohexyl-propiolic acid amide (4361-26-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C / Inert atmosphere; Schlenk technique

1.2: 2 h / -78 °C / Inert atmosphere; Schlenk technique

2.1: ammonia / tetrahydrofuran; ethanol / 2 h / 0 °C / Schlenk technique; Inert atmosphere

With n-butyllithium; ammonia; In tetrahydrofuran; ethanol; hexane;

DOI:10.1021/acs.orglett.0c02567

Reference yield:

3-cyclohexyl-2-propynenitrile (73542-37-7) → cyclohexyl-propiolic acid amide (4361-26-6)

Guidance literature:

With sulfuric acid; water; acetic acid; Hydrogenation;

upstream raw materials:

3-cyclohexyl-2-propynenitrile

cyclohexylpropynoic acid methyl ester

2-cyclohexylacetylene

Downstream raw materials:

(E)-3-cyclohexylacrylamide

Refernces