Eprosartan Ethyl Methyl Diester

Base Information

Chemical Name:Eprosartan Ethyl Methyl Diester
CAS No.:133486-13-2
Molecular Formula:C26H30N2O4S
Molecular Weight:466.601
Hs Code.:
DSSTox Substance ID:DTXSID90565991
Wikidata:Q82451386
Mol file:133486-13-2.mol

Synonyms:Eprosartan Ethyl Methyl Diester;133486-13-2;methyl 4-[[2-butyl-5-[(E)-3-ethoxy-3-oxo-2-(thiophen-2-ylmethyl)prop-1-enyl]imidazol-1-yl]methyl]benzoate;DRNXMWWTAZQPCI-RCCKNPSSSA-N;SCHEMBL1767191;SCHEMBL2059839;DTXSID90565991;(E)-alpha-[[2-butyl-1-[[4-(methoxy carbonyl)phenyl]methyl]-1H-imidazole-5-yl]methylene]-2-thiophenepropanoic acid ethyl ester;Methyl (E)-4-((2-butyl-5-(3-ethoxy-3-oxo-2-(thiophen-2-ylmethyl)prop-1-en-1-yl)-1H-imidazol-1-yl)methyl)benzoate;Methyl 4-[(2-butyl-5-{(1E)-3-ethoxy-3-oxo-2-[(thiophen-2-yl)methyl]prop-1-en-1-yl}-1H-imidazol-1-yl)methyl]benzoate

Suppliers and Price of Eprosartan Ethyl Methyl Diester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
EprosartanEthylMethylDiester
25mg
$ 155.00

Total 6 raw suppliers

Chemical Property of Eprosartan Ethyl Methyl Diester

Chemical Property:

PSA：98.66000
LogP:5.31130
XLogP3:5.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:13
Exact Mass:466.19262862
Heavy Atom Count:33
Complexity:663

Purity/Quality:

97% ^*data from raw suppliers

EprosartanEthylMethylDiester ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCCCC1=NC=C(N1CC2=CC=C(C=C2)C(=O)OC)C=C(CC3=CC=CS3)C(=O)OCC
Isomeric SMILES:CCCCC1=NC=C(N1CC2=CC=C(C=C2)C(=O)OC)/C=C(\CC3=CC=CS3)/C(=O)OCC
Uses Eprosartan (E590100) intermediate.

Technology Process of Eprosartan Ethyl Methyl Diester

There total 1 articles about Eprosartan Ethyl Methyl Diester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 133040-03-6
2-n-butyl-1-[(4-carbomethoxyphenyl)methyl]-1H-imidazol-5-carboxaldehyde

: 143468-96-6
3-ethoxy-3-oxo-2-(thien-3-ylmethyl)propanoic acid

: 133486-13-2
ethyl (αE)-α-[[2-n-butyl-1-[[4-(methoxycarbonyl)phenyl]methyl]-1H-imidazol-5-yl]methylene-2-thiophene]propionate

Guidance literature:: piperidine; propionic acid; In cyclohexane; at 25 - 35 ℃; for 17h; Heating / reflux;

Reference yield:

: 133486-13-2
ethyl (αE)-α-[[2-n-butyl-1-[[4-(methoxycarbonyl)phenyl]methyl]-1H-imidazol-5-yl]methylene-2-thiophene]propionate

: 133040-01-4,148674-39-9
eprosartan

Guidance literature:: ethyl (αE)-α-[[2-n-butyl-1-[[4-(methoxycarbonyl)phenyl]methyl]-1H-imidazol-5-yl]methylene-2-thiophene]propionate; With water; sodium hydroxide; In ethanol;

With hydrogenchloride; In ethanol; water; pH=4.5 - 6; Product distribution / selectivity;

Reference yield:

: 133486-13-2
ethyl (αE)-α-[[2-n-butyl-1-[[4-(methoxycarbonyl)phenyl]methyl]-1H-imidazol-5-yl]methylene-2-thiophene]propionate

: eprosartan mesylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / ethanol; water / 4 - 5 h / 25 - 60 °C

1.2: pH 5

2.1: 25 - 30 °C

3.1: acetone / 0 - 30 °C

With sodium hydroxide; In ethanol; water; acetone;