Benzoic acid, 4-(1-aminocyclopropyl)-, methyl ester, methanesulfonate (1:1)

Base Information

• Chemical Name: Benzoic acid, 4-(1-aminocyclopropyl)-, methyl ester, methanesulfonate (1:1)
• CAS No.: 1006037-04-2
• Molecular Formula: C12H17NO5S
• Molecular Weight: 287.337
• Mol file: 1006037-04-2.mol

Synonyms:Benzoic acid, 4-(1-aminocyclopropyl)-, methyl ester, methanesulfonate (1:1)

Chemical Property of Benzoic acid, 4-(1-aminocyclopropyl)-, methyl ester, methanesulfonate (1:1)

Chemical Property:

• PSA: 115.07000
• LogP: 2.70610

Purity/Quality:

4-(1-AMINOCYCLOPROPYL)BENZOIC ACID METHYL ESTER METHANESULFONATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoic acid, 4-(1-aminocyclopropyl)-, methyl ester, methanesulfonate (1:1)

There total 1 articles about Benzoic acid, 4-(1-aminocyclopropyl)-, methyl ester, methanesulfonate (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.9%

methanesulfonic acid (75-75-2,98527-29-8) + 4-(1-aminocyclopropyl)-benzoic acid methyl ester (1006037-03-1) → methyl 4-(1-aminocyclopropyl)benzoate MsOH salt (1006037-04-2)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 17h;

Reference yield: 98.8%

methyl 4-(1-aminocyclopropyl)benzoate MsOH salt (1006037-04-2) → 4-(1-aminocyclopropyl)-benzoic acid methyl ester (1006037-03-1)

Guidance literature:

With potassium phosphate; In Isopropyl acetate; water; at 20 ℃; for 2h; Product distribution / selectivity;

Reference yield:

methyl 4-(1-aminocyclopropyl)benzoate MsOH salt (1006037-04-2) + 5-fluoro-1-[4-trifluoromethyl-benzyl]-1H-indole-7-carboxylic acid (1050656-47-7) → methyl 4-{1-[({5-fluoro-1-[4-trifluoromethyl-benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl}benzoate (1050656-50-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

methanesulfonic acid

4-(1-aminocyclopropyl)-benzoic acid methyl ester

Downstream raw materials:

4-(1-aminocyclopropyl)-benzoic acid methyl ester

methyl 4-{1-[({5-fluoro-1-[4-trifluoromethyl-benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl}benzoate