4-Bromo-6-methylquinoline

Base Information

• Chemical Name: 4-Bromo-6-methylquinoline
• CAS No.: 1070879-23-0
• Molecular Formula: C₁₀H₈BrN
• Molecular Weight: 222.084
• Hs Code.: 2933499090
• Mol file: 1070879-23-0.mol

Synonyms:4-Bromo-6-methylquinoline;4-bromo-6-methylquinoline(SALTDATA: FREE);4-Bromo-6-methylquinoline98%

Chemical Property of 4-Bromo-6-methylquinoline

Chemical Property:

• PSA: 12.89000
• LogP: 3.30570

Purity/Quality:

97% ^*data from raw suppliers

4-Bromo-6-methylquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Bromo-6-methylquinoline

There total 2 articles about 4-Bromo-6-methylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

6-methylquinoline-N-oxide (4053-42-3) → 2-bromo-6-methyl-quinoline (302939-86-2) + 4-bromo-6-methylquinoline (1070879-23-0)

Guidance literature:

With N,N-dimethyl-formamide; phosphorus(V) oxybromide; In dichloromethane; at 0 - 25 ℃; for 6h; regioselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2016.07.083

Reference yield:

→ 4-bromo-6-methylquinoline (1070879-23-0)

Guidance literature:

Reference yield:

4-bromo-6-methylquinoline (1070879-23-0) → 6-methylquinoline-4-carboxylic acid (816448-94-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 70 °C / Inert atmosphere

2: sodium hydroxide; water / methanol / 25 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; triethylamine; sodium hydroxide; In methanol;

upstream raw materials:

6-methylquinoline-N-oxide

Downstream raw materials:

6-methylquinoline-4-carboxylic acid

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