Methyl 3-bromo-4-(((trifluoromethyl)sulfonyl)-oxy)-5-(trimethylsilyl)benzoate

Base Information

• Chemical Name: Methyl 3-bromo-4-(((trifluoromethyl)sulfonyl)-oxy)-5-(trimethylsilyl)benzoate
• CAS No.: 1242069-33-5
• Molecular Formula: C₁₂H₁₄BrF₃O₅SSi
• Molecular Weight: 435.291
• Hs Code.: 2916310090
• Mol file: 1242069-33-5.mol

Synonyms:Methyl 3-bromo-4-(((trifluoromethyl)sulfonyl)-oxy)-5-(trimethylsilyl)benzoate

Chemical Property of Methyl 3-bromo-4-(((trifluoromethyl)sulfonyl)-oxy)-5-(trimethylsilyl)benzoate

Chemical Property:

• PSA: 78.05000
• LogP: 4.09010

Purity/Quality:

Methyl 3-bromo-4-(((trifluoromethyl)sulfonyl)-oxy)-5-(trimethylsilyl)benzoate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 3-bromo-4-(((trifluoromethyl)sulfonyl)-oxy)-5-(trimethylsilyl)benzoate

There total 1 articles about Methyl 3-bromo-4-(((trifluoromethyl)sulfonyl)-oxy)-5-(trimethylsilyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3-bromo-2-oxo-2H-pyran-5-carboxylate (42933-07-3) + trifluoromethylsulfonic anhydride (358-23-6) + 4,4,5,5-tetramethyl-2-trimethylsilanylethynyl-[1,3,2]dioxaborolane (159087-46-4) → 3-bromo-4-trifluoromethanesulfonyloxy-5-trimethylsilanylbenzoic acid methyl ester (1242069-33-5) + 3-bromo-5-trifluoromethanesulfonyloxy-4-trimethylsilanyl-benzoic acid methyl ester (1242069-32-4)

Guidance literature:

methyl 3-bromo-2-oxo-2H-pyran-5-carboxylate; 4,4,5,5-tetramethyl-2-trimethylsilanylethynyl-[1,3,2]dioxaborolane; In 1,3,5-trimethyl-benzene; at 155 ℃; for 16h; Inert atmosphere;

With dihydrogen peroxide; sodium carbonate; In ethanol; at 20 ℃;

trifluoromethylsulfonic anhydride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; regioselective reaction;

DOI:10.1039/c0cc01345e

upstream raw materials:

methyl 3-bromo-2-oxo-2H-pyran-5-carboxylate

trifluoromethylsulfonic anhydride

4,4,5,5-tetramethyl-2-trimethylsilanylethynyl-[1,3,2]dioxaborolane