1H-Pyrrolo[1,2-a]benzimidazole-7,8-diamine,2,3-dihydro-(9CI)

Base Information

• Chemical Name: 1H-Pyrrolo[1,2-a]benzimidazole-7,8-diamine,2,3-dihydro-(9CI)
• CAS No.: 110209-31-9
• Molecular Formula: C₁₀H₁₂N₄
• Molecular Weight: 188.232
• Mol file: 110209-31-9.mol

Synonyms:1H-Pyrrolo[1,2-a]benzimidazole-7,8-diamine,2,3-dihydro-(9CI)

Chemical Property of 1H-Pyrrolo[1,2-a]benzimidazole-7,8-diamine,2,3-dihydro-(9CI)

Chemical Property:

• Melting Point: >150 °C (decomp)
• Boiling Point: 494.5±25.0 °C(Predicted)
• PKA: 7.18±0.20(Predicted)
• PSA: 69.86000
• Density: 1.60±0.1 g/cm3(Predicted)
• LogP: 2.30930

Purity/Quality:

2,3-dihydro-1H-Pyrrolo[1,2-a]benzimidazole-7,8-diamine 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Pyrrolo[1,2-a]benzimidazole-7,8-diamine,2,3-dihydro-(9CI)

There total 4 articles about 1H-Pyrrolo[1,2-a]benzimidazole-7,8-diamine,2,3-dihydro-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

7-Amino-2,3-dihydro-8-nitro-1H-pyrrolo<1,2-a>benzimidazole (110209-30-8) → 7,8-Diamino-2,3-dihydro-1H-pyrrolo<1,2-a>benzimidazole (110209-31-9)

Guidance literature:

With hydrazine hydrate; palladium on activated charcoal; In ethanol; Heating;

Reference yield:

N,N'-diacetyl-2,3-dinitro-1,4-phenylenediamine (7756-00-5) → 7,8-Diamino-2,3-dihydro-1H-pyrrolo<1,2-a>benzimidazole (110209-31-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 77 percent / CHCl₃ / Heating

2: 64 percent / formic acid, hydrogen peroxide

3: 81 percent / potassium hydroxide / H₂O; methanol / 0.5 h / warmed on a steam bath

4: 93 percent / hydrazine hydrate / 5percent palladium on charcoal / ethanol / Heating

With potassium hydroxide; formic acid; dihydrogen peroxide; hydrazine hydrate; palladium on activated charcoal; In methanol; ethanol; chloroform; water;

Reference yield:

7-Acetamido-2,3-dihydro-8-nitro-1H-pyrrolo<1,2-a>benzimidazole (110209-29-5) → 7,8-Diamino-2,3-dihydro-1H-pyrrolo<1,2-a>benzimidazole (110209-31-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / potassium hydroxide / H₂O; methanol / 0.5 h / warmed on a steam bath

2: 93 percent / hydrazine hydrate / 5percent palladium on charcoal / ethanol / Heating

With potassium hydroxide; hydrazine hydrate; palladium on activated charcoal; In methanol; ethanol; water;

upstream raw materials:

7-Amino-2,3-dihydro-8-nitro-1H-pyrrolo<1,2-a>benzimidazole

N,N'-diacetyl-2,3-dinitro-1,4-phenylenediamine

7-Acetamido-2,3-dihydro-8-nitro-1H-pyrrolo<1,2-a>benzimidazole

1,4-Diacetamido-2-nitro-3-N-pyrrolidinobenzene

Downstream raw materials:

1,7,8,9-Tetrahydroimidazo<4,5-e>pyrrolo<2,1-b>benzimidazole

1,7,8,9-Tetrahydrotriazolo<4,5-a>pyrrolo<2,1-b>benzimidazole

1,7,8,9-Tetrahydro-2-methylimidazo<4,5-e>pyrrolo<2,1-b>benzimidazole

9,10-Dihydro-2,3-diphenyl-8H-pyrrolo<1',2':1,2>imidazo<5,4-f>quinoxaline