3-fluoro-3-methylcyclobutan-1-amine hydrochloride

Base Information

• Chemical Name: 3-fluoro-3-methylcyclobutan-1-amine hydrochloride
• CAS No.: 1638768-85-0
• Molecular Formula: C₅H₁₀FN*ClH
• Molecular Weight: 139.6
• Hs Code.: 2921309990
• Mol file: 1638768-85-0.mol

Synonyms:3-fluoro-3-methylcyclobutan-1-amine hydrochloride;3-Fluoro-3-methylcyclobutanamine hydrochloride

Chemical Property of 3-fluoro-3-methylcyclobutan-1-amine hydrochloride

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

3-Fluoro-3-methylcyclobutan-1-amineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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Technology Process of 3-fluoro-3-methylcyclobutan-1-amine hydrochloride

There total 7 articles about 3-fluoro-3-methylcyclobutan-1-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

tert-butyl trans-(3-fluoro-3-methylcyclobutyl)carbamate → trans-3-fluoro-3-methylcyclobutanamine hydrochloride (1638768-85-0)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 1.5h;

DOI:10.1002/ejoc.201500746

Reference yield: 83.0%

tert-butyl cis-(3-fluoro-3-methylcyclobutyl)carbamate → cis-3-fluoro-3-methylcyclobutanamine hydrochloride (1638768-85-0)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 1.5h;

DOI:10.1002/ejoc.201500746

Reference yield:

3-methyl-trans(3-fluorocyclobutanecarboxylic acid) (1455037-43-0,1613330-60-1) → cis-3-fluoro-3-methylcyclobutanamine hydrochloride (1638768-85-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine; diphenyl phosphoryl azide / toluene / 100 °C

1.2: 100 °C

2.1: hydrogenchloride / methanol / 1.5 h / 20 °C

With hydrogenchloride; diphenyl phosphoryl azide; triethylamine; In methanol; toluene; 1.1: |Curtius Rearrangement / 1.2: |Curtius Rearrangement;

DOI:10.1002/ejoc.201500746

upstream raw materials:

3-methyl-trans(3-fluorocyclobutanecarboxylic acid)

benzyl trans-3-hydroxy-3-methylcyclobutanecarboxylate

benzyl 3-methyl-trans(3-fluorocyclobutanecarboxylate)

trans-benzyl 3-fluoro-3-methylcyclobutanecarboxylate

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