Ethyl 6-(Aminomethyl)Nicotinate Hydrochloride

Base Information

• Chemical Name: Ethyl 6-(Aminomethyl)Nicotinate Hydrochloride
• CAS No.: 1189434-55-6
• Molecular Formula: C9H13ClN2O2
• Molecular Weight: 216.66472
• Hs Code.: 2933399990
• Mol file: 1189434-55-6.mol

Synonyms:Ethyl 6-(Aminomethyl)Nicotinate Hydrochloride;Ethyl 6-(aminomethyl)nicotinate, HCl

Chemical Property of Ethyl 6-(Aminomethyl)Nicotinate Hydrochloride

Chemical Property:

• PSA: 65.21000
• LogP: 2.21930
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl6-(Aminomethyl)nicotinateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethyl 6-(Aminomethyl)Nicotinate Hydrochloride

There total 3 articles about Ethyl 6-(Aminomethyl)Nicotinate Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-ethoxycarbonyl-2-pyridinecarbonitrile (76196-79-7) → ethyl 6-(aminomethyl)-3-pyridinecarboxylate hydrochloride (1189434-55-6)

Guidance literature:

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In ethanol; water; for 12h; Inert atmosphere;

Reference yield:

3-pyridinecarboxylic acid ethyl ester (614-18-6) → ethyl 6-(aminomethyl)-3-pyridinecarboxylate hydrochloride (1189434-55-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: N,N-Dimethylcarbamoyl chloride / dichloromethane / 48 h / 20 °C / Inert atmosphere

3.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / ethanol; water / 12 h / Inert atmosphere

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; 3-chloro-benzenecarboperoxoic acid; N,N-Dimethylcarbamoyl chloride; In ethanol; dichloromethane; water;

Reference yield:

1-oxy-nicotinic acid ethyl ester (14906-63-9) → ethyl 6-(aminomethyl)-3-pyridinecarboxylate hydrochloride (1189434-55-6)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-Dimethylcarbamoyl chloride / dichloromethane / 48 h / 20 °C / Inert atmosphere

2: hydrogenchloride; palladium 10% on activated carbon; hydrogen / ethanol; water / 12 h / Inert atmosphere

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; N,N-Dimethylcarbamoyl chloride; In ethanol; dichloromethane; water;

upstream raw materials:

3-pyridinecarboxylic acid ethyl ester

1-oxy-nicotinic acid ethyl ester

5-ethoxycarbonyl-2-pyridinecarbonitrile

Downstream raw materials:

ethyl imidazo[1,5-a]pyridine-6-carboxylate

2-(imidazo[1,5-a]pyridin-6-ylmethoxy)-5-methoxybenzaldehyde

Refernces